Results 91 to 100 of about 4,183,748 (324)

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

Cancer Research, 2006
The anti-epidermal growth factor receptor (anti-EGFR) cetuximab has been proven to be efficient in metastatic colorectal cancer. The molecular mechanisms underlying the clinical response to this drug remain unknown.
A. Lièvre, J. Bachet, D. Le Corre, V. Boige, B. Landi, J. Emile, J. Côté, G. Tomasic, C. Penna, M. Ducreux, P. Rougier, F. Penault-Llorca, P. Laurent-Puig   +12 more
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Rapid progression of prostate cancer in men with a BRCA2 mutation. [PDF]

, 2008
Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients.
Ainsworth, Peter, Armel, S, Bellati, Christina, Couch, F, Cummings, S, Daly, Mary, Danquah, Jessica, Domchek, Susan, Eisen, Andrea, Foulkes, WD, Garber, Judy, Ghadirian, P, Gilchrist, Dawna, Hereditary Breast Cancer Study Group, Horsman, Douglas, Isaacs, Claudine, Karlan, Beth, Kim-Sing, Charmaine, Lynch, HT, Manoukian, Siranoush, Maugard, Christine, McKinnon, Wendy, Meschino, Wendy, Nam, R, Narod, SA, Nedelcu, Raluca, Neuhausen, S, Olopade, O, Pasini, Barbara, Poll, A, Saal, H, Stoppa-Lyonnet, D, Sun, P, Tulman, A, Tung, Nadine, Vichodez, G, Wagner, T, Warner, E, Weitzel, J, Wood, Marie   +39 more
core  

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS).

Nucleic Acids Research, 1989
We have improved the "polymerase chain reaction" (PCR) to permit rapid analysis of any known mutation in genomic DNA. We demonstrate a system, ARMS (Amplification Refractory Mutation System), that allows genotyping solely by inspection of reaction ...
C. Newton, A. Graham, L. Heptinstall, S. Powell, C. Summers, N. Kalsheker, J. Smith, A. Markham   +7 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Survival analysis of DNA mutation motifs with penalized proportional hazards

, 2018
Antibodies, an essential part of our immune system, develop through an intricate process to bind a wide array of pathogens. This process involves randomly mutating DNA sequences encoding these antibodies to find variants with improved binding, though ...
Feng, Jean, Matsen IV, Frederick A., Minin, Vladimir N., Shaw, David A., Simon, Noah   +4 more
core   +2 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

Molecular Therapy: Nucleic Acids, 2023
Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry, Chet R. Ojha, Kip J. Hermann, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak   +5 more
doaj  

Generating realistic null hypothesis of cancer mutational landscapes using SigProfilerSimulator

BMC Bioinformatics, 2020
Background Performing a statistical test requires a null hypothesis. In cancer genomics, a key challenge is the fast generation of accurate somatic mutational landscapes that can be used as a realistic null hypothesis for making biological discoveries ...
Erik N. Bergstrom, Mark Barnes, Iñigo Martincorena, Ludmil B. Alexandrov   +3 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source