Results 91 to 100 of about 4,355,944 (375)

Evolution Equation of Phenotype Distribution: General Formulation and Application to Error Catastrophe

, 2006
An equation describing the evolution of phenotypic distribution is derived using methods developed in statistical physics. The equation is solved by using the singular perturbation method, and assuming that the number of bases in the genetic sequence is ...
A. E. Mayo, A. Kashiwagi, E. Akin, E. Baake, H. A. Orr, H. Haken, H. Risken, J. F. Crow, J. Hofbauer, John G. Kemeny, K. Kaneko, Katsuhiko Sato, Kunihiko Kaneko, M. S. Waterman, N. G. van Kampen, P. M. Morse, R. E. Lenski, S. Kauffman   +17 more
core   +1 more source

Three distinct hematological malignancies from a single germ cell tumor: a case report

Journal of Medical Case Reports, 2020
Background The association between non seminomatous germ cell tumors (GCTs) and hematological malignancies of rare lineage has been described in the literature.
M. Spencer Chapman, P. C. May, E. Olavarria, E. Nadal Melsio   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Safe Mutations for Deep and Recurrent Neural Networks through Output Gradients

, 2018
While neuroevolution (evolving neural networks) has a successful track record across a variety of domains from reinforcement learning to artificial life, it is rarely applied to large, deep neural networks.
Chen, Jay, Clune, Jeff, Lehman, Joel, Stanley, Kenneth O.   +3 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Mechanisms of viral mutation

Cellular and Molecular Life Sciences, 2016
The remarkable capacity of some viruses to adapt to new hosts and environments is highly dependent on their ability to generate de novo diversity in a short period of time. Rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster
R. Sanjuán, P. Domingo-Calap
semanticscholar   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Vanishing cycles and mutation

, 2000
This is the writeup of a talk given at the European Congress of Mathematics, Barcelona. It considers Picard-Lefschetz theory from the Floer cohomology viewpoint.Comment: 20 pages, LaTeX2e.
A Floer, AI Bondal, D McDuff, D Salamon, Graded Lagrangian submanifolds, Homological algebra of mirror symmetry, K Fukaya, K Fukaya, Lagrangian two-spheres can be symplectically knotted, M Schwarz, M. Kontsevich, Lectures at ENS Paris, Spring, P Seidel, V Silva, VI Arnol’d   +13 more
core   +5 more sources

CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)

Haematologica, 2020
Nodal peripheral T-cell lymphoma not otherwise specified (PTCLNOS) remains a diagnosis encompassing a heterogenous group of PTCL cases not fitting criteria for more homogeneous subtypes.
Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini   +18 more
doaj   +1 more source