Results 91 to 100 of about 1,662,601 (323)
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Hybridizing PSM and RSM Operator for Solving NP-Complete Problems: Application to Travelling Salesman Problem [PDF]
IJCSI International Journal of Computer Science Issues, Vol. 9,
Issue 1, No 1, 2012, 374-378, 2012 In this paper, we present a new mutation operator, Hybrid Mutation (HPRM), for a genetic algorithm that generates high quality solutions to the Traveling Salesman Problem (TSP). The Hybrid Mutation operator constructs an offspring from a pair of parents by hybridizing two mutation operators, PSM and RSM.
arxiv
Patterns of mutations in TP53 mutated AML [PDF]
Best Practice & Research Clinical Haematology, 2018 TP53 mutated acute myeloid leukemia (AML) responds poorly to chemotherapy and has a short overall survival rate with a median of 5-9 months. Poor outcomes in TP53 mutated AML following chemotherapy have been observed and treatment options remain limited, although the presence of TP53 mutations alone should not be a barrier to therapy.
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Towards Advanced Phenotypic Mutations in Cartesian Genetic Programming [PDF]
arXiv, 2018 Cartesian Genetic Programming is often used with a point mutation as the sole genetic operator. In this paper, we propose two phenotypic mutation techniques and take a step towards advanced phenotypic mutations in Cartesian Genetic Programming. The functionality of the proposed mutations is inspired by biological evolution which mutates DNA sequences ...
arxiv
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
arXiv, 2010 In this paper we introduce mutation of Brauer trees. We show that our mutation of Brauer trees explicitly describes the tilting mutation of Brauer tree algebras introduced by Okuyama and Rickard.
arxiv
EMBO Molecular Medicine, 2010 AbstractSimilar cancer types may nevertheless differ widely in the genetic mutations they carry. In this Closeup, Kristensen and Borresen‐Dale discuss how identifying these mutations can define which therapy is most likely to succeed in eliminating the cancerous cells and how the methodology developed by Dias‐Santagata et al and described in this issue,
Anne Lise Børresen-Dale +1 more
openaire +3 more sources