Results 121 to 130 of about 2,130,071 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Role of mutation in pseudomonas aeruginosa biofilm development.

, 2009
The survival of bacteria in nature is greatly enhanced by their ability to grow within surface-associated communities called biofilms. Commonly, biofilms generate proliferations of bacterial cells, called microcolonies, which are highly recalcitrant, 3 ...
Collins, Samuel L., Webb, Jeremy S., Conibear Tim C. R., Collins Samuel L., Conibear, Tim C. R., Jeremy S. Webb, Webb Jeremy S., Samuel L. Collins, Samuel L Collins, Tim C R Conibear, Jeremy S Webb, Tim C. R. Conibear   +11 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CYSTIC-FIBROSIS PATIENTS FROM THE BLACK-SEA REGION - THE 1677DELTA MUTATION

, 1994
A 2 bp deletion in exon 10 of the CFTR gene, 1677delTA, which is very rare among CF chromosomes worldwide, was found to be a relatively common cause of cystic fibrosis in countries located in the region of the Black Sea. The frequency of the mutation was
GEORGIOU, C, KALAYDJIEVA, L, BARANOV, V, SAVOV, A, BOTEVA, K, JORDANOVA, A, DEMIRKOL, M, AKARSUBASI, A, AYDOGDU, S, TELATAR, M, TOLUN, A, ANGELICHEVA, D, KOPRUBASI, F, DEAN, M, IVASCHENKO, T, CONSTANTINOUDELTAS, CD, KUFARDJIEVA, A, KURDOGLU, G, Boteva, K., Tolun, A., Dean, M., Ivaschenko, T., Baranov, V., Kufardjieva, A., Köprübaşi, F., Aydoǧdu, S., Savov, A., Kalaydjieva, L., Georgiou, C., Jordanova, A., Kurdoǧlu, G., Angelicheva, D., Demirkol, M., Constantinou‐Deltas, C.D., Akarsubaşi, ALPER TUNGA, Telatar, M., M. Telatar, C. Georgiou, T. Ivaschenko, A. Kufardjieva, C. D. Constantinou-Deltas, A. Savov, M. Demirkol, A. Jordanova, A. Akarsubaşi, V. Baranov, A. Tolun, F. Köprübaşi, S. Aydo??du, G. Kurdo??lu, L. Kalaydjieva, M. Dean, D. Angelicheva, K. Boteva   +53 more
core   +1 more source

Induction of short stature and early maturity in lentil (Lens culinaris Medik.) through mutagenesis

Journal of Agriculture and Natural Resources
Induced mutagenesis is a pivotal tool for enhancing the genetic diversity and achieving targeted trait selection in pulse crops. In M2 and M3 generations of lentil (Lens culinaris Medik, var.
Rafiul Amin Laskar, Mohammad Rafiq Wani, Roshan Jahan, Samiullah Khan   +3 more
doaj   +1 more source

The Origin of Mutation

Science, 1914
n ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

X-ray-mediated isolated microspore mutagenesis: a system for salt-tolerant line development in wheat (Triticum aestivum L.)

Plant Methods
Background Establishing a technical system for in vitro mutagenesis and salt tolerance screening of wheat microspores is crucial for accelerating the homozygous stabilization of mutant progeny, creating novel salt‑tolerant wheat germplasm, and enabling ...
Wenlu Tan, Hui Li, Huijun Guo, Yongdun Xie, Huiyuan Li, Jiayu Gu, Hongchun Xiong, Yuping Ding, Le Xu, Linshu Zhao, Luxiang Liu   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Approaches for analyzing human mutations and nucleotide sequence variation : a report from the Seventh International Mutation Detection meeting, 2003

, 2004
The Seventh International Symposium on Mutations in the Human Genome, Mutation Detection 2003, was held during 2–6 July 2003 in Palm Cove near Cairns, Australia.
Syvänen, Ann-Christine,, Taylor, Graham R, Ann-Christine Syvänen, Graham R. Taylor   +3 more
core   +1 more source