Results 131 to 140 of about 1,981,585 (256)

VAX1 Mutation Associated with Microphthalmia, Corpus Callosum Agenesis, and Orofacial Clefting: The First Description of a VAX1 Phenotype in Humans

, 2011
Vax1 and Vax2 have been implicated in eye development and the closure of the choroid fissure in mice and zebrafish. We sequenced the coding exons of VAX1 and VAX2 in 70 patients with anophthalmia/microphthalmia (A/M).
Lemke, Greg, Yahyavi, Mani, Mohammed Youssef, Abouzeid, Hana, Schneider, Adele, Sherr, Elliott H., Bardakjian, Tanya, Anne M. Slavotinek, Youssef, Mohammed, Shaw, Gary, Tanya Bardakjian, Chao, Ryan, Ryan Chao, Schorderet, Daniel F., Greg Lemke, Hana Abouzeid, Mani Yahyavi, Adele Schneider, Elliott H. Sherr, Tomas Vacik, Slavotinek, Anne M., Vacik, Tomas, Gary Shaw, Daniel F. Schorderet   +23 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Das Intelligente Genom über die Entstehung des menschlichen Geistes durch Mutation und Selektion

, 1999
The Intelligent Genome: On the Formation of Human Intelligence via Mutation and Selection, by A.
Wendt, Dirk
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

X-ray-mediated isolated microspore mutagenesis: a system for salt-tolerant line development in wheat (Triticum aestivum L.)

Plant Methods
Background Establishing a technical system for in vitro mutagenesis and salt tolerance screening of wheat microspores is crucial for accelerating the homozygous stabilization of mutant progeny, creating novel salt‑tolerant wheat germplasm, and enabling ...
Wenlu Tan, Hui Li, Huijun Guo, Yongdun Xie, Huiyuan Li, Jiayu Gu, Hongchun Xiong, Yuping Ding, Le Xu, Linshu Zhao, Luxiang Liu   +10 more
doaj   +1 more source

CYSTIC-FIBROSIS PATIENTS FROM THE BLACK-SEA REGION - THE 1677DELTA MUTATION

, 1994
A 2 bp deletion in exon 10 of the CFTR gene, 1677delTA, which is very rare among CF chromosomes worldwide, was found to be a relatively common cause of cystic fibrosis in countries located in the region of the Black Sea. The frequency of the mutation was
GEORGIOU, C, KALAYDJIEVA, L, BARANOV, V, SAVOV, A, BOTEVA, K, JORDANOVA, A, DEMIRKOL, M, AKARSUBASI, A, AYDOGDU, S, TELATAR, M, TOLUN, A, ANGELICHEVA, D, KOPRUBASI, F, DEAN, M, IVASCHENKO, T, CONSTANTINOUDELTAS, CD, KUFARDJIEVA, A, KURDOGLU, G   +17 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Characterization of wheat oligo‐tiller mutant ot2 and fine mapping of the mutant gene Taot2

The Plant Genome
Tiller number is a crucial determinant of grain yield in wheat (Triticum aestivum L.), and identifying functional alleles can enhance our understanding of wheat tiller development. Here, we describe the ot2 wheat mutant, which exhibits a 91% reduction in
Chenxi Wang, Jiaxing Bai, Hongchun Xiong, Yongdun Xie, Jiayu Gu, Linshu Zhao, Huiyuan Li, Yuping Ding, Xinmei Guo, Huijun Guo, Luxiang Liu   +10 more
doaj   +1 more source

The gene encoding flavonol synthase contributes to lesion mimic in wheat

Crop Journal
Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection, and is characterized by a hypersensitive-response (HR) that closely linked to plant disease resistance.
Tingting Dong, Hongchun Xiong, Huijun Guo, Yongdun Xie, Linshu Zhao, Jiayu Gu, Huiyuan Li, Shirong Zhao, Yuping Ding, Xiyun Song, Luxiang Liu   +10 more
doaj   +1 more source