Results 161 to 170 of about 4,124,438 (399)
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Adaptive group mutation for tackling deception in genetic search [PDF]
, 2004 Copyright @ 2004 WSEASIn order to study the efficacy of genetic algorithms (GAs), a number of fitness landscapes have been designed and used as test functions.
Yang, S
core
The Importance of DNA Repair in Tumor Suppression
, 2004 The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions.
B. Vogelstein +8 more
core +1 more source
Quivers for silting mutation [PDF]
arXiv, 2015 We give a combinatorial mutation rule for Aihara's and Iyama's silting mutation. As an application, we reprove Keller-Yang's mutation rule for Ginzburg algebras, and obtain an analog of that rule for arbitrary dimension.
arxiv
Nihon rinsho. Japanese journal of clinical medicine, 2019 A point mutation is when a single base pair is altered. Point mutations can have one of three effects. First, the base substitution can be a silent mutation where the altered codon corresponds to the same amino acid.
Y. Yuasa
semanticscholar +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
, 2017 Mutation testing is a well-studied method for increasing the quality of a test suite. We designed LittleDarwin as a mutation testing framework able to cope with large and complex Java software systems, while still being easily extensible with new ...
A Parsai +14 more
core +1 more source
Annealing schedule from population dynamics
, 1999 We introduce a dynamical annealing schedule for population-based optimization algorithms with mutation. On the basis of a statistical mechanics formulation of the population dynamics, the mutation rate adapts to a value maximizing expected rewards at ...
A. Prügel-Bennett +15 more
core +1 more source