Results 161 to 170 of about 4,355,944 (375)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase [PDF]

, 2015
Yoshitatsu Sei, Xilin Zhao, Joanne Forbes, Silke Szymczak, Qing Li, Apurva Trivedi, Mark T. Voellinger, Grishma Joy, Jianying Feng, Millie Whatley, MaryPat Jones, Ursula L. Harper, Stephen J. Marx, Aradhana M. Venkatesan, Settara C. Chandrasekharappa, Mark Raffeld, Martha Quezado, Adeline Louie, Clara C. Chen, Ramona M. Lim, Richa Agarwala, Alejandro A. Schäffer, Marybeth S. Hughes, Joan E. Bailey‐Wilson, Stephen A. Wank   +24 more
openalex   +1 more source

Scalable identification of lineage-specific gene regulatory networks from metacells with NetID

Genome Biology
The identification of gene regulatory networks (GRNs) is crucial for understanding cellular differentiation. Single-cell RNA sequencing data encode gene-level covariations at high resolution, yet data sparsity and high dimensionality hamper accurate and ...
Weixu Wang, Yichen Wang, Ruiqi Lyu, Dominic Grün   +3 more
doaj   +1 more source

Mutations [PDF]

Science, 1905
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Spirotetramat resistance in Myzus persicae (Sulzer) (Hemiptera: Aphididae) and its association with the presence of the A2666V mutation [PDF]

, 2022
Paul A. Umina, Chris Bass, Anthony van Rooyen, Evatt Chirgwin, Aston L. Arthur, Adam Pym, Jo Mackisack, Andrew Mathews, Lisa S. Kirkland   +8 more
openalex   +1 more source

Genetic Analysis and Fine Mapping of QTL for the Erect Leaf in Mutant mths29 Induced through Fast Neutron in Wheat

Biology
The erect leaf plays a crucial role in determining plant architecture, with its growth and development regulated by genetic factors. However, there has been a lack of comprehensive studies on the regulatory mechanisms governing wheat lamina joint ...
Zhixin Yang, Jiayu Gu, Minghui Zhao, Xiaofeng Fan, Huijun Guo, Yongdun Xie, Jinfeng Zhang, Hongchun Xiong, Linshu Zhao, Shirong Zhao, Yuping Ding, Fuquan Kong, Li Sui, Le Xu, Luxiang Liu   +14 more
doaj   +1 more source

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Journal of the American Medical Association (JAMA), 2017
Karoline B. Kuchenbaecker, J. Hopper, D. Barnes, K. Phillips, T. Mooij, M. Roos-Blom, Sarah Jervis, F. V. van Leeuwen, R. Milne, N. Andrieu, D. Goldgar, M. Terry, M. Rookus, D. Easton, A. Antoniou, L. McGuffog, D. G. Evans, D. Barrowdale, D. Frost, J. Adlard, K. Ong, L. Izatt, M. Tischkowitz, R. Eeles, R. Davidson, Shirley V. Hodgson, Steve Ellis, C. Noguès, C. Lasset, D. Stoppa-Lyonnet, J. Fricker, Laurence Faivre, P. Berthet, M. Hooning, L. E. van der Kolk, C. Kets, M. Adank, Esther M. John, Wendy K. Chung, I. Andrulis, M. Southey, M. Daly, S. Buys, A. Osorio, C. Engel, K. Kast, Rita K Schmutzler, T. Caldés, A. Jakubowska, Jacques Simard, Michael L Friedlander, Sue-Anne McLachlan, E. Macháčková, L. Foretova, Y. Tan, Christian F. Singer, E. Oláh, A. Gerdes, B. Arver, H. Olsson   +59 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

A genome-wide survey of mutations in the Jurkat cell line [PDF]

, 2018
Louis Gioia, Azeem Siddique, Steven R. Head, Daniel R. Salomon, Andrew I. Su   +4 more
openalex   +1 more source