Results 201 to 210 of about 4,355,944 (375)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genome-wide selection inference at short tandem repeats. [PDF]

PLoS Genet
Huang B, Durvasula A, Mousavi N, Ziaei-Jam H, Maksimov M, Lohmueller KE, Gymrek M.   +6 more
europepmc   +1 more source

Origin and Evolution of Deleterious Mutations in Horses [PDF]

, 2019
Ludovic Orlando, Pablo Librado
openalex   +1 more source

MUTATION AND SELECTION [PDF]

Science, 1904
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2. [PDF]

Protein Sci
van Vlimmeren AE, Jiang Z, Karandur D, Applebaum Licht AT, Shah NH.   +4 more
europepmc   +1 more source

High microbiota reactivity of adult human intestinal IgA requires somatic mutations

, 2020
Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C. A. Hitch, Thomas Clavel, Vuk Cerovic, Hedda Wardemann, Oliver Pabst   +7 more
openalex   +1 more source

Allosteric Cross-Talk among Spike’s Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor

, 2021
Angelo Spinello, Andrea Saltalamacchia, Jure Borišek, Alessandra Magistrato   +3 more
openalex   +2 more sources

Mutation of YL Results in a Yellow Leaf with Chloroplast RNA Editing Defect in Soybean [PDF]

, 2020
Xiaowei Zhu, Yi Pan, Zhi Liu, Yucheng Liu, Deyi Zhong, Zongbiao Duan, Zhixi Tian, Baoge Zhu, Guoan Zhou   +8 more
openalex   +1 more source