Results 231 to 240 of about 4,355,944 (375)

POLE mutation combined with microcystic, elongated and fragmented (MELF) pattern invasion in endometrial carcinomas might be associated with poor survival in Chinese women

, 2020
Dan He, Hui Wang, Ying Dong, Yan Zhang, Jian Zhao, Conghui Lv, Xianjing Zheng, Dong Li, Ting Li   +8 more
openalex   +1 more source

Mutations in troABCD against Copper Overload in a copA Mutant of Streptococcus suis

, 2022
Yang Xia, Wei Peng, Yanna Wang, Kang Yan, Zewen Liu, Ting Gao, Keli Yang, Wei Liu, Rui Guo, Chang Li, Huanchun Chen, Yongxiang Tian, Danna Zhou, Weicheng Bei, Fangyan Yuan   +14 more
openalex   +2 more sources

Correction of a pathogenic gene mutation in human embryos

Nature, 2017
Hong Ma, N. Marti-Gutierrez, Park Sw, Jun Wu, Young Hee Lee, Keiichiro Suzuki, A. Koski, Dongmei Ji, T. Hayama, Riffat Ahmed, H. Darby, C. Vandyken, Yongmin Li, Eunju Kang, Park Ar, Daesik Kim, Sang-Tae Kim, Jianhui Gong, Ying Gu, D. Battaglia, Sacha A. Krieg, David M. Lee, D. Wu, D. Wolf, S. Heitner, Belmonte Jci, P. Amato, Jin-Soo Kim, S. Kaul, S. Mitalipov   +29 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early-life <i>DNMT3A</i> mutations. [PDF]

Hemasphere
Derks LLM, Müskens KF, van Roosmalen MJ, de Graaf AO, Epskamp N, Trabut L, Hagelaar R, Jansen JH, Lindemans CA, van Bergen MGJM, van Boxtel R, Belderbos ME.   +11 more
europepmc   +1 more source

Exome-wide somatic mutation characterization of small bowel adenocarcinoma

, 2018
Ulrika A. Hänninen, Riku Katainen, Tomas Tanskanen, Roosa‐Maria Plaketti, Riku Laine, Jiri Hamberg, Ari Ristimäki, ­Eero Pukkala, Minna Taipale, Jukka‐Pekka Mecklin, Linda Forsström, Esa Pitkänen, Kimmo Palin, Niko Välimäki, Netta Mäkinen, Lauri A. Aaltonen   +15 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Correlation analysis between EGFR gene mutation status, ALK positivity and demographic data, tumor biomarkers, radiological and pathological features in patients with lung adenocarcinoma. [PDF]

Front Oncol
Zhang XF, Zhang X, Zhao L, Zhao ZL.
europepmc   +1 more source

Tissue-specific mutation accumulation in human adult stem cells during life

Nature, 2016
Francis Blokzijl, J. Ligt, M. Jager, Valentina Sasselli, Sophie F. Roerink, Nobuo Sasaki, Meritxell Huch, S. Boymans, E. Kuijk, P. Prins, I. Nijman, I. Martincorena, M. Mokry, C. L. Wiegerinck, S. Middendorp, Toshiro Sato, Gerald Schwank, E. Nieuwenhuis, M. Verstegen, L. V. D. Laan, J. Jonge, J. Ijzermans, R. Vries, M. Wetering, M. Stratton, H. Clevers, E. Cuppen, R. Boxtel   +27 more
semanticscholar   +1 more source