Results 231 to 240 of about 1,662,601 (323)

Direct measurement of the male germline mutation rate in individuals using sequential sperm samples. [PDF]

Nat Commun
Shoag JE, Srinivasa A, Loh CA, Liu MH, Lassen E, Melanaphy S, Costa BM, Grońska-Pęski M, Jabara NT, Picciotto S, Choi U, Bohorquez AD, Barbieri CE, Callum P, Skytte AB, Evrony GD.   +15 more
europepmc   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

A novel GJA3 mutation causing autosomal dominant congenital perinuclear cataracts. [PDF]

BMC Ophthalmol
Zhu Y, Li N, Yao K, Wang W, Li J.
europepmc   +1 more source

Mutations Induced by X-Rays [PDF]

, 1930
R. Ruggles Gates
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Correlation analysis on epidermal growth factor receptor (EGFR) mutations and clinicopathological characteristics in lung adenocarcinomas. [PDF]

Front Oncol
Wang H, Ji C, Zhou C, Li H.
europepmc   +1 more source

The Induction of Mutations by a Carcinogen

, 1949
Louise C. Strong
openalex   +1 more source

MUTATION AMONG HOG-CHOLERA BACILLI [PDF]

, 1923
Marion L. Orcutt
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Coevolution of Atypical BRAF and KRAS Mutations in Colorectal Tumorigenesis. [PDF]

Mol Cancer Res
Woolley CE, Domingo E, Fernandez-Tajes J, Pennel KAF, Roxburgh P, Edwards J, Richman SD, Maughan TS, Kerr DJ, Soriano I, Tomlinson IPM.   +10 more
europepmc   +1 more source