Results 111 to 120 of about 5,512,789 (304)
Ecology and EvolutionAccurate estimates of mutation rates derived from genome‐wide mutation accumulation (MA) data are fundamental to understanding basic evolutionary processes. The rapidly improving high‐throughput sequencing technologies provide unprecedented opportunities
Takahiro Maruki +3 more
doaj +1 more source
Sorting out mutation rates [PDF]
Proceedings of the National Academy of Sciences, 1999 It has been over half a century since Salvador Luria experienced an epiphany while watching a (no doubt illegal) slot machine in a country club in Bloomington, IN (1). The experiment that resulted, the Luria–Delbruck fluctuation test, resides in the molecular biology wing of the Museum of Elegant Science along with the Hershey–Chase, the PaJaMo, the ...
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Editorial: High-impact respiratory RNA virus diseases
Frontiers in Veterinary Science, 2023 Victor Manuel Petrone-García +2 more
doaj +1 more source
Biological Roles of Protein-Coding Tandem Repeats in the Yeast Candida Albicans
Journal of Fungi, 2018 Tandem repeat (TR) DNA mutates faster than other DNA by insertion and deletion of repeats. Large parts of eukaryotic proteomes are encoded by ORFs containing protein-coding TRs (TR-ORFs, pcTRs) with largely unknown biological consequences.
Matt Wilkins, Ningxin Zhang, Jan Schmid
doaj +1 more source
Mitochondrial DNA mutation in an Italian family with Leber hereditary optic neuropathy
, 1991 Mitochondrial (mt) DNA from a Southern Italian family with Leber hereditary optic neuropathy was analyzed for the presence of the reported mutation at position 11778 of the ND4 subunit gene.
Pontecorvi, Alfredo
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Time-dependent mutation rate profiles.
, 2021 Each treatment strategy u(t) leads to a characteristic mutation intensity profile S(t, u(t))μ(u(t)), which gives the rate of gaining a rescue mutant as a function of time.
Teemu Kuosmanen (11473623) +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
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