Results 101 to 110 of about 846,289 (308)

Sorting out mutation rates [PDF]

Proceedings of the National Academy of Sciences, 1999
It has been over half a century since Salvador Luria experienced an epiphany while watching a (no doubt illegal) slot machine in a country club in Bloomington, IN (1). The experiment that resulted, the Luria–Delbruck fluctuation test, resides in the molecular biology wing of the Museum of Elegant Science along with the Hershey–Chase, the PaJaMo, the ...
openaire   +2 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

CYSTIC-FIBROSIS PATIENTS FROM THE BLACK-SEA REGION - THE 1677DELTA MUTATION

, 1994
A 2 bp deletion in exon 10 of the CFTR gene, 1677delTA, which is very rare among CF chromosomes worldwide, was found to be a relatively common cause of cystic fibrosis in countries located in the region of the Black Sea. The frequency of the mutation was
GEORGIOU, C, KALAYDJIEVA, L, BARANOV, V, SAVOV, A, BOTEVA, K, JORDANOVA, A, DEMIRKOL, M, AKARSUBASI, A, AYDOGDU, S, TELATAR, M, TOLUN, A, ANGELICHEVA, D, KOPRUBASI, F, DEAN, M, IVASCHENKO, T, CONSTANTINOUDELTAS, CD, KUFARDJIEVA, A, KURDOGLU, G   +17 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Independent mutational events are rare in the ATM gene: Haplotype prescreening enhances mutation detection rate

, 2003
Mutations in the ATM gene are responsible for the autosomal recessive disorder ataxia,telangiectasia (A-T). Many different mutations have been identified using various techniques, with detection efficiencies ranging from 57 to 85%.
Castellvi-Bel, S., Mitui, M., Fontan, G., Carvalho, BTC, Fernandez, L., Campbell, C., Thorstenson, Y., Gatti, R. A., Lai, C. H., Monros, E., Sun, X, Coutinho, G., Porras, O.   +12 more
core   +1 more source

Impacts of mutation effects and population size on mutation rate in asexual populations: a simulation study [PDF]

, 2010
Background In any natural population, mutation is the primary source of genetic variation required for evolutionary novelty and adaptation. Nevertheless, most mutations, especially those with phenotypic effects, are harmful and are consequently removed ...
Xiaoqian Jiang, Mingjing Zhang, Shiheng Tao, Wang Xiaojuan, Huang Zhuoran, Mu Baolin, Baolin Mu, Tao Shiheng, Jiang Xiaoqian, Zhang Mingjing, Zhuoran Huang, Xiaojuan Wang   +11 more
core   +1 more source

Algorithm for calculating nucleotide mutation rate.

, 2023
Algorithm for calculating nucleotide mutation rate.
Mohammad Amaz Uddin (16871956), Hanan Aljuaid (8538138), Refat Khan Pathan (16871953), Ananda Mohan Paul (16871959), Zuhal Y. Hamd (16871965), Md. Imtiaz Uddin (16871962), Mayeen Uddin Khandaker (10509188)   +6 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

What can we infer about mutation calling by using time‐series mutation accumulation data and a Bayesian Mutation Finder?

Ecology and Evolution
Accurate estimates of mutation rates derived from genome‐wide mutation accumulation (MA) data are fundamental to understanding basic evolutionary processes. The rapidly improving high‐throughput sequencing technologies provide unprecedented opportunities
Takahiro Maruki, April Ozere, Jack Freeman, Melania E. Cristescu   +3 more
doaj   +1 more source

Biological Roles of Protein-Coding Tandem Repeats in the Yeast Candida Albicans

Journal of Fungi, 2018
Tandem repeat (TR) DNA mutates faster than other DNA by insertion and deletion of repeats. Large parts of eukaryotic proteomes are encoded by ORFs containing protein-coding TRs (TR-ORFs, pcTRs) with largely unknown biological consequences.
Matt Wilkins, Ningxin Zhang, Jan Schmid
doaj   +1 more source