Results 81 to 90 of about 846,289 (308)

The effect of mutation rate variation.

, 2012
The figure shows the effect on parameter estimation when the mutation rate is varied along the genome alignment. We split the alignment into segments geometrically distributed with mean length 500 bp and 2 kbp, and the mutation rate is then scaled by a ...
Thomas Mailund (51584), Kasper Munch (17843), Gerton Lunter (27174), Aylwyn Scally (109051), Mikkel H. Schierup (53286), Anders E. Halager (109039), Michael Westergaard (109040), Julien Y. Dutheil (109041), Kay Prüfer (109049), Asger Hobolth (7266), Lars N. Andersen (109045)   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Higher Rates of Viral Evolution in Chronic Hepatitis B Patients Linked to Predicted T Cell Epitopes

Viruses
The impact of hepatitis B virus (HBV) diversity and evolution on disease progression is not well-understood. This study aims to compare intra-individual viral evolution in two groups of chronic hepatitis B (CHB) patients, using antiviral treatment ...
Magnus Illum Dalegaard, Anni Winckelmann, Ulrik Fahnøe, Alexander P. Underwood, Anders Gorm Pedersen, Signe Bollerup, Jens Bukh, Nina Weis   +7 more
doaj   +1 more source

Somatic mutations substantially increase the per‐generation mutation rate in the conifer Picea sitchensis

Evolution Letters, 2019
The rates and biological significance of somatic mutations have long been a subject of debate. Somatic mutations in plants are expected to accumulate with vegetative growth and time, yet rates of somatic mutations are unknown for conifers, which can ...
Vincent C. T. Hanlon, Sarah P. Otto, Sally N. Aitken   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The hierarchical island model revisited

Genetics Selection Evolution, 2000
Formulae were derived for the genetic differentiation between populations within a metapopulation (FSM), and between metapopulations (FMT) as functions of migration and mutation rates, size and number of populations and metapopulations. We show that FMT =
Couvet Denis, Vigouroux Yves
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii

mBio
Mutation rates in bacteria are an important determinant of adaptation to new environments and success in different niches. In some bacterial pathogens, “hypermutator” variants—most often associated with mutations in components of the DNA mismatch repair ...
Francesca L. Short, Ram Maharjan, Liping Li, Nusrat Afrin, Natasha Delgado, Christine J. Boinett, Julian Parkhill, Amy K. Cain, Ian T. Paulsen   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Mutation rate data

, 2017
Data on genomic mutation rate measured for the ...
Magwene, Paul M., Meeks, Brianna, Murphy, Helen A., Skelly, Daniel   +3 more
core   +1 more source