Results 71 to 80 of about 846,289 (308)
Trends in the Use of Proper Methods for Estimating Mutation Rates in Fluctuation Experiments
Axioms, 2023 The accurate quantification of mutation rates holds significance across diverse fields, including evolution, cancer research, and antimicrobial resistance. Eighty years ago, Luria and Delbrück demonstrated that the proper quantification of mutation rates
Guillem A. Devin, Alejandro Couce
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Determination of the mutation rate of a retrovirus [PDF]
Journal of Virology, 1988 The mutation rate of Rous sarcoma virus (RSV) was measured. Progeny descended from a single virion were collected after one replication cycle, and seven regions of the genome were analyzed for mutations by denaturing-gradient gel electrophoresis. In all, 65,250 nucleotides were screened, yielding nine mutations, and the RSV mutation rate was calculated
J M, Leider, P, Palese, F I, Smith
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Evolution of the mutation rate.
, 2018 Ancestral genomic mutation rates are shown as squares, evolved mutation rates at generation 3000 as circles, and 95% confidence intervals of mutation rate estimates are shaded. Each evolved strain's mean change in mutation rate is shown as the percentage
Andreas Wagner (3323) +3 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Microbiology Spectrum, 2023 Global warming is increasing human exposure to pathogens and has already had an impact on human health. Vibrio parahaemolyticus, a major pathogen causing foodborne illness, accumulates in numerous aquatic organisms and can be affected by environmental ...
Weishan Zhang +6 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria
mBioThe rate, spectrum, and biases of mutations represent a fundamental force shaping biological evolution. Convention often attributes oxidative DNA damage as a major driver of spontaneous mutations.
Owen F. Hale +2 more
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Life, 2015 The standard genetic code (SGC) is central to molecular biology and its origin and evolution is a fundamental problem in evolutionary biology, the elucidation of which promises to reveal much about the origins of life.
Steven E. Massey
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MUTATOR GENES AND SELECTION FOR THE MUTATION RATE IN BACTERIA [PDF]
Genetics, 1975 ABSTRACT Gene frequencies in populations of haploid, asexual organisms are described by linear recurrence equations. Several models in which the mutation rate is controlled by one locus and the fitness is controlled at one or more other loci are developed.
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Evolution of mutation rates in bacteria [PDF]
Molecular Microbiology, 2006 SummaryEvolutionary success of bacteria relies on the constant fine‐tuning of their mutation rates, which optimizes their adaptability to constantly changing environmental conditions. When adaptation is limited by the mutation supply rate, under some conditions, natural selection favours increased mutation rates by acting on allelic variation of the ...
Erick, Denamur, Ivan, Matic
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