Results 71 to 80 of about 5,512,789 (304)

Phylogenomic and Structural Analysis of the Monkeypox Virus Shows Evolution towards Increased Stability

open access: yesViruses, 2022
Monkeypox is an infectious zoonotic disease caused by an Orthopoxvirus and results in symptoms similar to smallpox. In a recent outbreak, monkeypox virus (MPXV) cases have been reported globally since May 2022, and the numbers are increasing.
Priya Yadav   +2 more
doaj   +1 more source

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +4 more sources

4x4 mutation rate matrices.

open access: yes, 2023
This study analyzes the SARS-CoV-2 genome sequence mutations by modeling its nucleotide mutations as a stochastic process in both the time-series and spatial domain of the gene sequence.
Maverick Lim Kai Rong (15374417)   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Trends in the Use of Proper Methods for Estimating Mutation Rates in Fluctuation Experiments

open access: yesAxioms, 2023
The accurate quantification of mutation rates holds significance across diverse fields, including evolution, cancer research, and antimicrobial resistance. Eighty years ago, Luria and Delbrück demonstrated that the proper quantification of mutation rates
Guillem A. Devin, Alejandro Couce
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Elevated rates and biased spectra of mutations in anaerobically cultured lactic acid bacteria

open access: yesmBio
The rate, spectrum, and biases of mutations represent a fundamental force shaping biological evolution. Convention often attributes oxidative DNA damage as a major driver of spontaneous mutations.
Owen F. Hale   +2 more
doaj   +1 more source

Genetic Code Evolution Reveals the Neutral Emergence of Mutational Robustness, and Information as an Evolutionary Constraint

open access: yesLife, 2015
The standard genetic code (SGC) is central to molecular biology and its origin and evolution is a fundamental problem in evolutionary biology, the elucidation of which promises to reveal much about the origins of life.
Steven E. Massey
doaj   +1 more source

The impact of global warming on the signature virulence gene, thermolabile hemolysin, of Vibrio parahaemolyticus

open access: yesMicrobiology Spectrum, 2023
Global warming is increasing human exposure to pathogens and has already had an impact on human health. Vibrio parahaemolyticus, a major pathogen causing foodborne illness, accumulates in numerous aquatic organisms and can be affected by environmental ...
Weishan Zhang   +6 more
doaj   +1 more source

A directed mutation operator for real coded genetic algorithms [PDF]

open access: yes, 2010
Copyright @ Springer-Verlag Berlin Heidelberg 2010.Developing directed mutation methods has been an interesting research topic to improve the performance of genetic algorithms (GAs) for function optimization. This paper introduces a directed mutation (DM)
Yang, S   +8 more
core   +1 more source

Home - About - Disclaimer - Privacy