Results 61 to 70 of about 846,289 (308)
The rate of polygenic mutation
Genetical Research, 1988 SummaryBy application of the neutral model of phenotypic evolution, quantitative estimates of the rate of input of genetic variance by polygenic mutation can be extracted from divergence experiments as well as from the response of an inbred base population to selection.
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The mutation rate to Huntington's chorea [PDF]
Journal of Medical Genetics, 1982 The problems of estimating the mutation rate to Huntington's chorea, or the proportion of new mutants among all sufferers, are discussed. The available survey data are reviewed. The prevalence of sporadic phenotypes, which include new mutations, is probably less than 2·5%. New mutants probably make up around 0·1% or less of all sufferers.
M, Shaw, A, Caro
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
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Frontiers in Cellular and Infection MicrobiologyBackgroundListeria (L.) monocytogenes is primarily transmitted via contaminated food and can cause listeriosis, an infection often associated with sepsis and meningitis in at-risk individuals. Accurate outbreak detection relies on whole genome sequencing
Astrid Füszl +11 more
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Viruses, 2022 Monkeypox is an infectious zoonotic disease caused by an Orthopoxvirus and results in symptoms similar to smallpox. In a recent outbreak, monkeypox virus (MPXV) cases have been reported globally since May 2022, and the numbers are increasing.
Priya Yadav +2 more
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Environmental tuning of mutation rates [PDF]
Environmental Microbiology, 2005 Summary Through their life cycles, bacteria experience many different environments in which the relationship between available energy resources and the frequency and the nature of various stresses is highly variable.
Saint-Ruf, Claude, Matic, Ivan
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Time-dependent mutation rate profiles.
, 2021 Each treatment strategy u(t) leads to a characteristic mutation intensity profile S(t, u(t))μ(u(t)), which gives the rate of gaining a rescue mutant as a function of time.
Teemu Kuosmanen (11473623) +5 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Applied SciencesExtracts, fractions and the pure compound epifriedelanol of the medicinal plant Synadenium glaucescens have antibacterial properties. Herbal products are generally considered less prone to resistance development than conventional antimicrobials, as they ...
Zaituni Msengwa +11 more
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BMC Genomics, 2012 Background Chromosomal inversions have been pervasive during the evolution of the genus Drosophila, but there is significant variation between lineages in the rate of rearrangement fixation. D.
Guillén Yolanda, Ruiz Alfredo
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