Results 41 to 50 of about 5,512,789 (304)

Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair

Cells, 2021
We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing.
Scott Alexander Lujan, Thomas A. Kunkel
doaj   +1 more source

The rate of mutation of a single gene [PDF]

Nucleic Acids Research, 2009
The rate of mutation refers to the probability that a unit length of DNA (generally a base pair) mutates with time. Fluctuation analysis or mutant accumulation assays applied to phenotypic changes measure mutation rates of cells. However, only a few phenotypic changes indicative of mutations are known thus limiting the analysis to those rare genes ...
Balin, Samuel J., Cascalho, Marilia
openaire   +2 more sources

The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers [PDF]

, 2004
<p>Introduction: The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to have an earlier ...
Antoniou, A.C., Spurdle, A.B., Cook, M.R., Purdie, David M., Susan Peock, Hopper, John L., Easton, Douglas, Newman, B, kConFaB, Antoniou, AC, Kelemen, Livia, Tobias, E.S., Smith, Paula, Pandeya, N, Giles, GG, Beth Newman, Giles, Graham, Chenevix-Trench, Georgia, Cook, Margaret, Apicella, Carmel, Nirmala Pandeya, Easton, Douglas F., Melissa C Southey, Southey, M.C., Antoniou, Antonis, Purdie, David, Chenevix-Trench, G, Cook, MR, Peock, Susan, Apicella, C., Giles, G.G., Apicella, C, Purdie, D.M., Xiaoqing Chen, Antoniou, Antonis C., David L Duffy, Margaret R Cook, Duffy, David, Newman, Beth, ABCFS, Duffy, D.L., Pandeya, N., Amanda B Spurdle, Dite, Gillian S., Giles, Graham G., Georgia Chenevix-Trench, Smith, Paula L., Newman, B., Gillian S Dite, Hopper, J.L., John L Hopper, Southey, MC, Chen, Xiaoqing, Chen, X., Cook, Margaret R., Chen, X, Duffy, David L., EMBRACE Study Collaborators, Purdie, DM, Hopper, JL, Easton, D.F., Dite, Gillian, Douglas F Easton, David M Purdie, Southey, Melissa, Smith, P.L., AJBCS, Chenevix-Trench, G., Dite, GS, Spurdle, Amanda, Peock, S., Antonis C Antoniou, Chevenix-Trench, Georgia, Dite, G.S., Spurdle, Amanda B., Carmel Apicella, Spurdle, AB, Kelemen, L., Pandeya, Nirmala, Smith, PL, Kelemen, L, Easton, DF, Southey, Melissa C., Paula L Smith, Hopper, John, Livia Kelemen, Duffy, DL, Peock, S, Graham G Giles   +88 more
core   +3 more sources

An adaptive mutation operator for particle swarm optimization [PDF]

, 2008
Copyright @ 2008 MICParticle swarm optimization (PSO) is an effcient tool for optimization and search problems. However, it is easy to betrapped into local optima due to its in-formation sharing mechanism.
Yang, S, Li, C, Korejo, I
core   +2 more sources

Novel Fosfomycin Resistance Mechanism in Pseudomonas entomophila Due to Atypical Pho Regulon Control of GlpT

Antibiotics
Background/Objectives: Pseudomonas entomophila is a ubiquitous bacterium capable of killing insects of different orders and has become a model for host–pathogen studies and a promising tool for biological pest control.
Laura Sánchez-Maroto, Pablo Gella, Alejandro Couce   +2 more
doaj   +1 more source

Substitution mutation rate.

, 2023
Monkeypox is a double-stranded DNA virus with an envelope and is a member of the Poxviridae family’s Orthopoxvirus genus. This virus can transmit from human to human through direct contact with respiratory secretions, infected animals and humans, or ...
Mohammad Amaz Uddin (16871956), Hanan Aljuaid (8538138), Refat Khan Pathan (16871953), Ananda Mohan Paul (16871959), Zuhal Y. Hamd (16871965), Md. Imtiaz Uddin (16871962), Mayeen Uddin Khandaker (10509188)   +6 more
core   +1 more source

Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos

Entropy, 2023
During the progression of some cancer cells, the degree of genome instability may increase, leading to genome chaos in populations of malignant cells. While normally chaos is associated with ergodicity, i.e., the state when the time averages of relevant ...
Sergey Shityakov, Viacheslav Kravtsov, Ekaterina V. Skorb, Michael Nosonovsky   +3 more
doaj   +1 more source

Evolution of mutation rates in bacteria [PDF]

Molecular Microbiology, 2006
SummaryEvolutionary success of bacteria relies on the constant fine‐tuning of their mutation rates, which optimizes their adaptability to constantly changing environmental conditions. When adaptation is limited by the mutation supply rate, under some conditions, natural selection favours increased mutation rates by acting on allelic variation of the ...
Erick, Denamur, Ivan, Matic
openaire   +2 more sources

Adaptive mutation with fitness and allele distribution correlation for genetic algorithms [PDF]

, 2006
Copyright @ 2006 ACMIn this paper, a new gene based adaptive mutation scheme is proposed for genetic algorithms (GAs), where the information on gene based fitness statistics and on gene based allele distribution statistics are correlated to explicitly ...
Yang, S, Shengxiang Yang, Yang, Shengxiang, Uyar, S   +3 more
core   +1 more source

Profound Differences in Virus Population Genetics Correspond to Protection from CD4 Decline Resulting from Feline Lentivirus Coinfection

Viruses, 2010
CD4 decline is a hallmark of disease onset in individuals infected with Feline Immunodeficiency Virus (FIV) or Human Immunodeficiency Virus type 1 (HIV-1).
Abinash Padhi, Howard Ross, Julie Terwee, Mary Poss, Sue VandeWoude   +4 more
doaj   +1 more source