Results 41 to 50 of about 846,289 (308)

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +1 more source

Novel Fosfomycin Resistance Mechanism in Pseudomonas entomophila Due to Atypical Pho Regulon Control of GlpT

open access: yesAntibiotics
Background/Objectives: Pseudomonas entomophila is a ubiquitous bacterium capable of killing insects of different orders and has become a model for host–pathogen studies and a promising tool for biological pest control.
Laura Sánchez-Maroto   +2 more
doaj   +1 more source

Ergodicity Breaking and Self-Destruction of Cancer Cells by Induced Genome Chaos

open access: yesEntropy, 2023
During the progression of some cancer cells, the degree of genome instability may increase, leading to genome chaos in populations of malignant cells. While normally chaos is associated with ergodicity, i.e., the state when the time averages of relevant ...
Sergey Shityakov   +3 more
doaj   +1 more source

Muller's ratchet and mutational meltdowns [PDF]

open access: yes, 1993
We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ...
Lynch, M.   +8 more
core   +1 more source

Profound Differences in Virus Population Genetics Correspond to Protection from CD4 Decline Resulting from Feline Lentivirus Coinfection

open access: yesViruses, 2010
CD4 decline is a hallmark of disease onset in individuals infected with Feline Immunodeficiency Virus (FIV) or Human Immunodeficiency Virus type 1 (HIV-1).
Abinash Padhi   +4 more
doaj   +1 more source

Estimation of the SNP Mutation Rate in Two Vegetatively Propagating Species of Duckweed

open access: yesG3: Genes, Genomes, Genetics, 2020
Mutation rate estimates for vegetatively reproducing organisms are rare, despite their frequent occurrence across the tree of life. Here we report mutation rate estimates in two vegetatively reproducing duckweed species, Lemna minor and Spirodela ...
George Sandler   +3 more
doaj   +1 more source

Spontaneous Mutation Rates and Spectra of Respiratory-Deficient Yeast

open access: yesBiomolecules, 2023
The yeast petite mutant was first discovered in the yeast Saccharomyces cerevisiae, which shows growth stress due to defects in genes encoding the respiratory chain. In a previous study, we described that deletion of the nuclear-encoded gene MRPL25 leads
Xinyu Tu   +5 more
doaj   +1 more source

The scale of mutational variability in the murid genome.

open access: yes, 2005
Mutation rates vary across mammalian genomes, but little is known about the scale over which this variation occurs. Knowledge of the magnitude and scale of mutational variation is required to understand the processes that drive mutation, and is essential
Keightley, Peter, Gaffney, Daniel
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

Selection on mutators is not frequency-dependent

open access: yeseLife, 2019
The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent.
Yevgeniy Raynes, Daniel Weinreich
doaj   +1 more source

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