Results 21 to 30 of about 846,289 (308)

Exact Distribution of Linkage Disequilibrium in the Presence of Mutation, Selection, or Minor Allele Frequency Filtering

Frontiers in Genetics, 2020
Linkage disequilibrium (LD), often expressed in terms of the squared correlation (r2) between allelic values at two loci, is an important concept in many branches of genetics and genomics.
Jiayi Qu, Stephen D. Kachman, Dorian Garrick, Rohan L. Fernando, Hao Cheng   +4 more
doaj   +1 more source

Rates of Spontaneous Mutation

Genetics, 1998
Abstract Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose genomes contain ca. 104 bases, are roughly 1 per genome per replication for lytic viruses and roughly 0.1 per genome per ...
J W, Drake, B, Charlesworth, D, Charlesworth, J F, Crow   +3 more
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Monotonicity of fitness landscapes and mutation rate control [PDF]

, 2016
A common view in evolutionary biology is that mutation rates are minimised. However, studies in combinatorial optimisation and search have shown a clear advantage of using variable mutation rates as a control parameter to optimise the performance of ...
Channon
core   +1 more source

Rate-enhancing Single Amino Acid Mutation for Hydrolases: A Statistical Profiling

, 2021
We reported the statistical profiling for rate-enhancing mutant hydrolases with single amino acid substitution. We constructed an integrated structure-kinetics database, IntEnzyDB, which contains 3,907 experimentally characterized hydrolase kinetics ...
Sarah K., Torrence, Li, Yuan, Zhongyue, Yang, Bailu, Yan, Xinchun, Ran, Qianzhen, Shao, Yaoyukun, Jiang   +6 more
core   +1 more source

An analysis of the spontaneous mutation rate measurement in filamentous fungi

Genetics and Molecular Biology, 2003
Mutations related to gene methG1 of Aspergillus nidulans were analyzed, in order to study a mathematical model for the determination of the mutation rate per nucleus per generation, in filamentous fungi. A replica plating technique was used to inoculate,
Marta S. Baracho, Ivanhoé R. Baracho
doaj   +1 more source

Evolution of the mutation rate [PDF]

Trends in Genetics, 2010
Understanding the mechanisms of evolution requires information on the rate of appearance of new mutations and their effects at the molecular and phenotypic levels. Although procuring such data has been technically challenging, high-throughput genome sequencing is rapidly expanding knowledge in this area.
openaire   +2 more sources

Epidemiological and Genomic Analysis of SARS-CoV-2 in 10 Patients From a Mid-Sized City Outside of Hubei, China in the Early Phase of the COVID-19 Outbreak

Frontiers in Public Health, 2020
A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing Coronavirus Disease 2019 (COVID-19) pandemic.
Jinkun Chen, Evann E. Hilt, Fan Li, Huan Wu, Zhuojing Jiang, Qinchao Zhang, Jiling Wang, Yifang Wang, Ziqin Li, Jialiang Tang, Shangxin Yang, Shangxin Yang   +11 more
doaj   +1 more source

Population Genomics Insights into the First Wave of COVID-19

Life, 2021
Full-genome-sequence computational analyses of the SARS-coronavirus (CoV)-2 genomes allow us to understand the evolutionary events and adaptability mechanisms.
Maria Vasilarou, Nikolaos Alachiotis, Joanna Garefalaki, Apostolos Beloukas, Pavlos Pavlidis   +4 more
doaj   +1 more source

Substitution mutation rate.

, 2023
Monkeypox is a double-stranded DNA virus with an envelope and is a member of the Poxviridae family’s Orthopoxvirus genus. This virus can transmit from human to human through direct contact with respiratory secretions, infected animals and humans, or ...
Mohammad Amaz Uddin (16871956), Hanan Aljuaid (8538138), Refat Khan Pathan (16871953), Ananda Mohan Paul (16871959), Zuhal Y. Hamd (16871965), Md. Imtiaz Uddin (16871962), Mayeen Uddin Khandaker (10509188)   +6 more
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The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers [PDF]

, 2004
<p>Introduction: The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to have an earlier ...
Antoniou, A.C., Spurdle, A.B., Cook, M.R., Purdie, David M., Susan Peock, Hopper, John L., Easton, Douglas, Newman, B, kConFaB, Antoniou, AC, Kelemen, Livia, Tobias, E.S., Smith, Paula, Pandeya, N, Giles, GG, Beth Newman, Giles, Graham, Chenevix-Trench, Georgia, Cook, Margaret, Apicella, Carmel, Nirmala Pandeya, Easton, Douglas F., Melissa C Southey, Southey, M.C., Antoniou, Antonis, Purdie, David, Chenevix-Trench, G, Cook, MR, Peock, Susan, Apicella, C., Giles, G.G., Apicella, C, Purdie, D.M., Xiaoqing Chen, Antoniou, Antonis C., David L Duffy, Margaret R Cook, Duffy, David, Newman, Beth, ABCFS, Duffy, D.L., Pandeya, N., Amanda B Spurdle, Dite, Gillian S., Giles, Graham G., Georgia Chenevix-Trench, Smith, Paula L., Newman, B., Gillian S Dite, Hopper, J.L., John L Hopper, Southey, MC, Chen, Xiaoqing, Chen, X., Cook, Margaret R., Chen, X, Duffy, David L., EMBRACE Study Collaborators, Purdie, DM, Hopper, JL, Easton, D.F., Dite, Gillian, Douglas F Easton, David M Purdie, Southey, Melissa, Smith, P.L., AJBCS, Chenevix-Trench, G., Dite, GS, Spurdle, Amanda, Peock, S., Antonis C Antoniou, Chevenix-Trench, Georgia, Dite, G.S., Spurdle, Amanda B., Carmel Apicella, Spurdle, AB, Kelemen, L., Pandeya, Nirmala, Smith, PL, Kelemen, L, Easton, DF, Southey, Melissa C., Paula L Smith, Hopper, John, Livia Kelemen, Duffy, DL, Peock, S, Graham G Giles   +88 more
core   +1 more source