Results 11 to 20 of about 5,512,789 (304)
Mutation Rate For Evolvable Hardware
, 2007 Evolvable hardware (EHW) refers to a selfreconfiguration hardware design, where the configuration is under the control of an evolutionary algorithm (EA). A lot of research has been done in this area several different EA have been introduced. Every time a specific EA is chosen for solving a particular problem, all its components, such as population size,
Emanuele Stomeo +2 more
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Rate-enhancing Single Amino Acid Mutation for Hydrolases: A Statistical Profiling [PDF]
, 2021 We reported the statistical profiling for rate-enhancing mutant hydrolases with single amino acid substitution. We constructed an integrated structure-kinetics database, IntEnzyDB, which contains 3,907 experimentally characterized hydrolase kinetics ...
Sarah K., Torrence +6 more
core +2 more sources
Journal of Virology, 2010 ABSTRACT Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses.
Sanjuán, Rafael +4 more
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Estimating the Rate of Mutation to a Mutator Phenotype
Axioms, 2023 A mutator is a variant in a population of organisms whose mutation rate is higher than the average mutation rate in the population. For genetic and population dynamics reasons, mutators are produced and survive with much greater frequency than anti-mutators (variants with a lower-than-average mutation rate).
Isaac Vázquez-Mendoza +4 more
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A spatial mutation model with increasing mutation rates
Journal of Applied Probability, 2023 AbstractWe consider a spatial model of cancer in which cells are points on the d-dimensional torus $\mathcal{T}=[0,L]^d$ , and each cell with $k-1$ mutations acquires a kth mutation at rate $\mu_k$ . We assume that the mutation rates $\mu_k$ are increasing, and we find the asymptotic waiting time for the first cell to acquire k mutations as the ...
Brian Chao, Jason Schweinsberg
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Antibiotics, 2022 Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S.
Jan Balansky +12 more
doaj +1 more source
Preprint: Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer
, 2022 SUMMARY Mutation rate optimisation drives evolution and immune evasion of bacteria and lentiviral strains, including HIV. Whether evolving cancer lineages similarly adapt mutation rates to increase tumour cell fitness is unknown.
Daniel Hochhauser +29 more
core +1 more source
Rate-Perturbing Single Amino Acid Mutation for Hydrolases: A Statistical Profiling
, 2021 Hydrolases are a critical component for modern chemical, pharmaceutical, and environmental sciences. Identifying mutations that enhance catalytic efficiency presents a roadblock to design and to discover new hydrolases for broad academic and industrial ...
Bailu Yan (11437462) +6 more
core +2 more sources
Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions [PDF]
, 2014 Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well characterized.
John A. D. Aston +40 more
core +1 more source
Genetics, 1998 Abstract The stability of the human genome requires that mutations in the germ line be exceptionally rare events. While most mutations are neutral or have deleterious effects, a limited number of mutations are required for adaptation to environmental changes. Drake has provided evidence that DNA-based microbes have evolved a mechanism to
A L, Jackson, L A, Loeb
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