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A Fresh Approach to a Special Type of the Luria–Delbrück Distribution
Axioms, 2022 The mutant distribution that accommodates both fitness and plating efficiency is an important class of the Luria–Delbrück distribution. Practical algorithms for computing this distribution do not coincide with the theoretically most elegant ones, as ...
Qi Zheng
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Vibrio vulnificus mutation rate: an in vitro approach [PDF]
Frontiers in Microbiology, 2023 Vibrio vulnificus is a multi-host pathogenic species currently subdivided into five phylogenetic lineages (L) plus one pathovar with the ability to infect fish due to a transmissible virulence plasmid.
Francisco Jose Roig Molina +4 more
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Complexities of Viral Mutation Rates [PDF]
Journal of Virology, 2018 ABSTRACT Many viruses evolve rapidly. This is due, in part, to their high mutation rates. Mutation rate estimates for over 25 viruses are currently available. Here, we review the population genetics of virus mutation rates. We specifically cover the topics of mutation rate estimation, the forces that drive the evolution of mutation rates, and
Kayla M Peck, Adam S Lauring
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Frequency of Promoter Mutations in Real-World Analysis of 2,092 Thyroid Carcinoma Patients [PDF]
Endocrinology and Metabolism, 2022 Background Telomerase reverse transcriptase (TERT) promoter mutations are associated with increased recurrence and mortality in patients with thyroid carcinoma.
Heera Yang +12 more
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Signals interpreted as archaic introgression appear to be driven primarily by faster evolution in Africa [PDF]
Royal Society Open Science, 2020 Non-African humans appear to carry a few per cent archaic DNA due to ancient inter-breeding. This modest legacy and its likely recent timing imply that most introgressed fragments will be rare and hence will occur mainly in the heterozygous state.
William Amos
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Evolution of the germline mutation rate across vertebrates [PDF]
Nature, 2023 Lucie A Bergeron +2 more
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Emergence of Genomic Diversity in the Spike Protein of the “Omicron” Variant
Viruses, 2023 SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus) has constantly been evolving into different forms throughout its spread in the population. Emerging SARS-CoV-2 variants, predominantly the variants of concern (VOCs), could have an impact on the ...
Surajit Basak +4 more
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Journal of Virology, 2010 ABSTRACT Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses.
Sanjuán, Rafael +4 more
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Reversible Transitions in a Fluctuation Assay Modify the Tail of Luria–Delbrück Distribution
Axioms, 2023 We consider a fluctuation test experiment in which cell colonies were grown from a single cell until they reach a given population size and were then exposed to treatment.
Pavol Bokes +2 more
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The mutation rate and cancer [PDF]
Proceedings of the National Academy of Sciences, 1996 The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor. Models of tumorigenesis have considered the relative importance of mutation and selection.
Tomlinson, I, Novelli, MR, Bodmer, W
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