Results 191 to 200 of about 5,512,789 (304)

Germline de novo mutation rate of the highly heterozygous amphioxus genome. [PDF]

Mol Biol Evol
Xue J, Tao L, Cao J, Wu L, Li G, Li C.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Developmental speed and chronological time exert opposing effects on the spontaneous mutation rate in <i>Chironomus riparius</i>. [PDF]

Evol Lett
Bulut B, Pfenninger M.
europepmc   +1 more source

Time's up: mutation rate and lifespan. [PDF]

Signal Transduct Target Ther, 2022
Cremer A, Abplanalp WT, Rieger MA.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Spatial variation in the mutation rate within the plant shoot apical meristem. [PDF]

Proc Natl Acad Sci U S A
Amundson KR, Marimuthu MPA, Nguyen O, Sarika K, DeMarco IJ, Phan A, Henry IM, Comai L.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Low mutation rate but high male-bias in the germline of a short-lived opossum. [PDF]

Genetics
Peña-García Y, Wang RJ, Raveendran M, Harris RA, Samollow PB, Rogers J, Hahn MW.   +6 more
europepmc   +1 more source

Evidence of Site-Specific and Male-Biased Germline Mutation Rate in a Wild Songbird. [PDF]

Genome Biol Evol, 2023
Zhang H, Lundberg M, Tarka M, Hasselquist D, Hansson B.   +4 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source