Results 231 to 240 of about 2,822,760 (305)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Acquired resistance in Stenotrophomonas maltophilia: Mechanisms underlying the shift from multidrug to pandrug resistance. [PDF]

Eur J Microbiol Immunol (Bp)
Vattanaviboon P, Dulyayangkul P, Tipanyo P, Mongkolsuk S, Charoenlap N.   +4 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Detection of germline variants in human population chronically exposed to high level natural background radiation in Kerala coast. [PDF]

Genes Environ
Jain V, Saini D, Sabarinathan R, Das B.
europepmc   +1 more source

Chronic infections can generate SARS-CoV-2-like bursts of viral evolution without epistasis. [PDF]

Virus Evol
Rodríguez-Horta E, Strahan J, Dinner AR, Barton JP.   +3 more
europepmc   +1 more source

Correction for Wang et al., Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Clonal analysis of a case with fluid overload-associated large B-cell lymphoma evolving from primary large B-cell lymphoma of the central nervous system. [PDF]

Ann Hematol
Ito Y, Kogure Y, Maeshima AM, Hosoba R, Fukuhara S, Munakata W, Chiba K, Okada A, Shiraishi Y, Narita Y, Izutsu K, Kataoka K.   +11 more
europepmc   +1 more source

Mutational biases and selection in mitochondrial genomes: insights from a comparative analysis of natural and laboratory populations of Caenorhabditis elegans. [PDF]

G3 (Bethesda)
Schifano A, Bergthorsson U, Katju V.
europepmc   +1 more source

Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung. [PDF]

Toxicol Sci
Faske JB, Gong B, LeBlanc DP, Funk J, Zhou G, Kehm S, White PA, Robison T, Zeller A, Yauk CL, Marchetti F, Parsons BL.   +11 more
europepmc   +1 more source