Results 231 to 240 of about 3,248,558 (306)

Advances in Colorectal Cancer Cell Biology and Clonal Evolution. [PDF]

Int J Mol Sci
Toghey S, Harvey-Jones EJ, Towler JD, Hafkamp CJH, Chong IY.   +4 more
europepmc   +1 more source

Outcomes following lower-intensity therapy with venetoclax in patients with NPM1-mutated Acute Myeloid Leukemia are highly dependent upon co-occurring mutations [PDF]

Curtis A. Lachowiez, Seongseok Yun, Maël Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero‐Marroquin, Joseph Cannova, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carré, Gaspar Aspas Requena, Jenny O’Nions, Faisal Basheer, John Laurie, Ellen Madarang, Richard Dillon, Sanam Loghavi, Joshua F. Zeidner, Daniel A. Pollyea, Justin M. Watts, Jad Othman   +24 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

bZIP-Domain Variant Allele Frequency Helps to Refine Risk Stratification in CEBPA-Mutated AML. [PDF]

Biomedicines
Zhang K, Ma X, Lu X, Ruan G, Wei F, Jiang H, Chang Y, Huang X, Zhao X.   +8 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Association of oncogene mutations with clinical and histopathological characteristics in patients with metastatic melanoma. [PDF]

An Bras Dermatol
Quintiliano JA, Nunes AF, Pinheiro-Hubinger-Stauffer L.   +2 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review). [PDF]

Oncol Rep
Sharma U, Song J, Kandu H, Zhu Y, Dai Z.
europepmc   +1 more source

Les mutations économiques de la musique enregistrée redéfinissent le rôle de ses acteurs

, 2017
Oriane Sundstom
openalex   +1 more source