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Mutation and Mutation Screening
2013Molecular techniques have created the opportunity for great advances in plant mutation genetics and the science of mutation breeding. The powerful targeted induced local lesions in genomes (TILLING) technique has introduced the possibility of reverse genetics-the ability to screen for mutations at the DNA level prior to assessing phenotype. Fundamental
Lee, L Slade +4 more
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Mutation Detection and Mutation Databases
cclm, 1998AbstractDetection of mutations in genes is vital throughout biology, however, this activity is time-consuming, expensive and requires a high degree of skill. This is unsatisfactory in a field which is increasing importance. Around 10–12 methods are commonly used with some predominating.
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Microsatellite instability: The mutator that mutates the other mutator
Nature Medicine, 1996Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676–681).
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