The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology [PDF]
Frontiers in Genetics, 2019 The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event.
Federica Natali, Giulia Rancati
exaly +5 more sources
Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites. [PDF]
PLoS ONE, 2016 Malaria control efforts have been continuously stymied by drug-resistant strains of Plasmodium falciparum, which typically originate in Southeast Asia prior to spreading into high-transmission settings in Africa.
Andrew H Lee, David A Fidock
doaj +4 more sources
Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription. [PDF]
PLoS ONE, 2015 Streptococcus pyogenes chromosomal island M1 (SpyCIM1) integrates by site-specific recombination into the 5' end of DNA mismatch repair (MMR) gene mutL in strain SF370SmR, blocking transcription of it and the downstream operon genes.
Christina Hendrickson +7 more
doaj +4 more sources
Split MutT prevents the mutator phenotype of mutT-deficient Escherichia coli [PDF]
Genes and EnvironmentBackground The Escherichia coli MutT (NudA) protein catalyzes the hydrolysis of an oxidized form of dGTP, 8-oxo-7,8-dihydro-dGTP (8-hydroxy-dGTP), and the spontaneous mutation frequency is elevated in E. coli cells deficient in the mutT gene.
Hiroyuki Kamiya
doaj +3 more sources
Frontiers in Microbiology, 2012 We recently showed that a prophage-like Streptococcus pyogenes chromosomal island (SpyCI) controls DNA mismatch repair (MMR) and other repair functions in M1 genome strain SF370 by dynamic excision and reintegration into the 5’ end of mutL in response to
Scott V Nguyen, W Michael Mcshan
exaly +4 more sources
A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae [PDF]
eLife, 2021 Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis and DNA repair, most of this work has focused on a few laboratory strains. Much less is known about the phenotypic effects of natural variation within S. cerevisiae’
Pengyao Jiang +5 more
doaj +2 more sources
An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness [PDF]
Viruses, 2021 Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a model to ...
Erika Trompet +5 more
doaj +2 more sources
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine [PDF]
Nature Communications, 2020 ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon ...
Diletta Fontana +29 more
doaj +2 more sources
Chloroplast- and mitochondrion-specific random C-to-T mutagenesis for forward genetics of organelle genomes. [PDF]
Plant JSignificance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Kosaka N +6 more
europepmc +2 more sources
Accelerated mutator phenotype in a clinical Aspergillus fumigatus isolate contributes to adaptive evolution [PDF]
Emerging Microbes and InfectionsThe opportunistic pathogen Aspergillus fumigatus represents a major threat to immunocompromised individuals and is increasingly resistant to antifungal therapies.
Yinggai Song +6 more
doaj +2 more sources