Results 11 to 20 of about 9,839 (200)
Estimating the Rate of Mutation to a Mutator Phenotype
Axioms, 2023 A mutator is a variant in a population of organisms whose mutation rate is higher than the average mutation rate in the population. For genetic and population dynamics reasons, mutators are produced and survive with much greater frequency than anti ...
Isaac Vázquez-Mendoza +4 more
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Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia
Genetics and Molecular Biology, 2004 The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes.
Flávio Monteiro Ayres +3 more
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Estimating the mutation rate to mutator phenotypes
, 2023 The mutator phenotype hypothesis by Loeb et al. (1974) proposes the existence of cells that have a higher mutation rate than the rest of the cell population and that, consequently, occasionally favor the appearance of mutant cells. Such cells, often called mutator cells, are related to drug resistance, genetic instability, and increasing the ...
Vazquez-Mendoza, Isaac +2 more
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Genetics and Molecular Biology, 2006 The TK6 lymphoblastoid cell line is known to be mismatch repair (MMR) and p53 proficient. Deficiency in MMR results in a mutator phenotype characterized by microsatellite instability (MSI) and increased hprt mutant frequency (MF).
Flávio Monteiro Ayres +3 more
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XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature [PDF]
Nature Communications, 2020 Xeroderma Pigmentosum group C (XP-C) is a rare genetic disorder characterised by deficient DNA repair leading to skin and internal cancer, but the latter is not well understood molecularly.
Andrey A. Yurchenko +5 more
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Carcinogenesis trajectories [PDF]
Frontiers in Cell and Developmental BiologyIntroductionCancer origin patterns significantly influence cancer phenotypes and hallmark characteristics.MethodIn the present review, four distinct carcinogenesis trajectories that contribute to malignant transformation: mutator phenotype, chromosomal ...
Rui Wang, Zhaopeng Yan
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Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype [PDF]
Molecular Oncology, 2020 Douglas E. Brash, Michael M. Seidman
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A transient mutational burst occurs during yeast colony development [PDF]
Molecular Systems BiologyCharacterizing the contribution of mutators to mutation accumulation is essential for understanding cellular adaptation and diseases like cancer. By measuring single and double mutation rates, including point mutations, segmental duplications, and ...
Nicolas Agier +8 more
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An Organismal CNV Mutator Phenotype Restricted to Early Human Development [PDF]
Cell, 2017 Pengfei Liu +2 more
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A Mutator Phenotype Promoting the Emergence of Spontaneous Oxidative Stress-Resistant Mutants in Campylobacter jejuni. [PDF]
Appl Environ Microbiol, 2017 Campylobacter jejuni is a leading cause of foodborne illnesses worldwide. As a microaerophilic organism, C. jejuni must be able to defend against oxidative stress encountered both in the host and in the environment ...
Dai L, Sahin O, Tang Y, Zhang Q.
europepmc +3 more sources