Results 191 to 200 of about 488,983 (281)

Large Electrostrain and High Optical Transmittance via Oxygen Octahedron Rotation Disordering in KNN Ceramics

Advanced Science, EarlyView.
Chemical disorder engineering reconfigures BO6 oxygen‐octahedron rotations in lead‐free K0.5Na0.5NbO3 ceramics from local ordering into a random distribution, dissolving the longstanding trade‐off between optical transparency and electromechanical strain.
Xia Luo, Jian Wang, Yu Tan, Jiyang Xie, Thamil Selvi Velayutham, Wanbiao Hu   +5 more
wiley   +1 more source

Mutual exclusivity bias and spatial reasoning in Vision-Language Models

Despite rapid advancements in machine learning, enabling models to generalize beyond their training data, they still lag significantly behind the learning efficiency of young children.
Thai, Ngoc Anh
core  

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Interpreting Mutation Co-Occurrence in Cancer Genomics Under Biological Context. [PDF]

Cancers (Basel)
Jang YH, Hwang W.
europepmc   +1 more source

Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer. [PDF]

Biol Direct, 2015
Srihari S, Singla J, Wong L, Ragan MA.
europepmc   +1 more source

Cryo‐EM and NMR Reveal a Membrane‐Gated Doc2B–Munc13‐1 Complex and a Helical Doc2B‐SNARE‐Binding Interface

Advanced Science, EarlyView.
Biophysical studies of Doc2B yield a cryo‐electron microscopy structure of its complex with the synaptic vesicle priming factor Munc13‐1 and its binding site to the SNARE complex that mediates synaptic vesicle fusion. These and other results suggest a novel model whereby Doc2 proteins regulate neurotransmitter release through sequential interactions ...
Cyrus T. Rastegar, Julia Powell, Aleksandra Wosztyl, Guillaume David, Klaudia Jaczynska, Xiao‐chen Bai, Yan Han, Zhe Chen, Josep Rizo   +8 more
wiley   +1 more source

Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

J Autoimmun, 2019
Betteridge Z, Tansley S, Shaddick G, Chinoy H, Cooper RG, New RP, Lilleker JB, Vencovsky J, Chazarain L, Danko K, Nagy-Vincze M, Bodoki L, Dastmalchi M, Ekholm L, Lundberg IE, McHugh N, UKMyonet contributors.   +16 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Co-mutation patterns and survival associations in lung cancer: a comparative analysis of Swedish and global cohorts. [PDF]

Acta Oncol
Karlowatz N, Köhn L, Patthey C, Nilsson J, Johansson M.   +4 more
europepmc   +1 more source

Using MEMo to discover mutual exclusivity modules in cancer. [PDF]

Curr Protoc Bioinformatics, 2013
Ciriello G, Cerami E, Aksoy BA, Sander C, Schultz N.   +4 more
europepmc   +1 more source