Results 1 to 10 of about 1,044,115 (187)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities [PDF]

Cell Reports, 2016
ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance ...
Kumar Sanjiv, Anna Hagenkort, José Manuel Calderón-Montaño, Tobias Koolmeister, Philip M. Reaper, Oliver Mortusewicz, Sylvain A. Jacques, Raoul V. Kuiper, Niklas Schultz, Martin Scobie, Peter A. Charlton, John R. Pollard, Ulrika Warpman Berglund, Mikael Altun, Thomas Helleday   +14 more
doaj   +4 more sources

Targeting synthetic lethality in colorectal cancer [PDF]

Chinese Medical Journal
Pingting Chen, Junsha An, Jianbo Zhou, Jiayu Zou, Cheng Peng, Fu Peng, Jing Ni   +6 more
doaj   +4 more sources

Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. [PDF]

PLoS Computational Biology, 2015
Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously.
Alexandra Jacunski, Scott J Dixon, Nicholas P Tatonetti   +2 more
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The tumor therapy landscape of synthetic lethality [PDF]

Nature Communications, 2021
Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http:/
Biyu Zhang, Chen Tang, Yanli Yao, Xiaohan Chen, Chi Zhou, Zhiting Wei, Feiyang Xing, Lan Chen, Xiang Cai, Zhiyuan Zhang, Shuyang Sun, Qi Liu   +11 more
doaj   +3 more sources

The role of protein interactions in mediating essentiality and synthetic lethality. [PDF]

PLoS ONE, 2013
Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these "essential genes" play a central role in biological function.
David Talavera, David L Robertson, Simon C Lovell   +2 more
doaj   +3 more sources

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

Acta Pharmaceutica Sinica B, 2021
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li, Jieqiong You, Qian Wu, Wen Meng, Qiaojun He, Bo Yang, Chengliang Zhu, Ji Cao   +7 more
doaj   +3 more sources

MGANSL: multi-network representation generating with generative adversarial network for synthetic lethality prediction [PDF]

BMC Bioinformatics
Background: Cancer is a complex disease that arises from the simultaneous mutations of multiple biological molecules. An effective therapeutic strategy is to exploit synthetic lethality (SL) by targeting the SL partner of cancer driver genes ...
Jinxin Li, Xinguo Lu, Zihao Li, Xing Liu, Hongrui Liu, Jingjing Ruan   +5 more
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Synthetic lethality in TP53-mutant acute myeloid leukemia [PDF]

Blood Advances
Shyam A. Patel
doaj   +2 more sources

Research progress for the development of anti-tumor drugs based on synthetic lethality

生物医学转化, 2022
Synthetic lethality describes a phenomenon where mutation of any one of two non-lethal genes does not affect cell survival, whereas mutation of both genes significantly compromise cell viability.
Chen Pei, Mu Bo, Bin Huachao, Yang Shengyong   +3 more
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Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer

BMC Cancer, 2023
Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells.
Shane O’Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad, Andy Fedoriw   +8 more
doaj   +1 more source