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DNA Damage, Mutagenesis, and DNA Repair [PDF]
Journal of Nucleic Acids, 2010 This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to ...
Ashis Basu +3 more
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PTEN in DNA damage repair [PDF]
Cancer Letters, 2012 The ability of DNA repair in a cell is vital to its genomic integrity and thus to the normal functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established tumor suppressor gene that induces apoptosis and controls cell growth by inhibiting the PI3K/AKT pathway.
Mei Ming, Yu-Ying He
exaly +3 more sources
Nature, 2003 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury.
Michaela Cichon +2 more
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Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays
STAR Protocols, 2021 Summary: Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and supply blood cells. Efficient methods for isolation of HSPCs are required. Here, we present protocols for the isolation of human and murine HSPCs using manual and FACS-
Alfredo Rodríguez +5 more
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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife, 2021 BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen +13 more
doaj +1 more source
DNA Repair by Reversal of DNA Damage [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to ...
Chengqi, Yi, Chuan, He
openaire +3 more sources
Research progress on the role and mechanism of DNA damage repair in germ cell development
Frontiers in Endocrinology, 2023 In the complex and dynamic processes of replication, transcription, and translation of DNA molecules, a large number of replication errors or damage can occur which lead to obstacles in the development process of germ cells and result in a decreased ...
Yan Wang +9 more
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DNA damage and repair in atherosclerosis [PDF]
Cardiovascular Research, 2006 There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair.
Mahmoudi, M., Mercer, J., Bennett, M.
openaire +4 more sources
Radiobiology Summaries: DNA Damage and Repair [PDF]
Clinical Oncology, 2021 No abstract available.
Chalmers, A.J., Carruthers, R.D.
openaire +3 more sources
DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
Frontiers in Genetics, 2022 DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity.
Menghui Wang, Chuan Xie
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