Results 41 to 50 of about 377,653 (310)

DNA Damage, Repair, and Cancer Metabolism

Frontiers in Oncology, 2018
Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored.
Marc-Olivier Turgeon, Nicholas J. S. Perry, George Poulogiannis, George Poulogiannis   +3 more
doaj   +1 more source

DNA Repair Pathways in Cancer Therapy and Resistance

Frontiers in Pharmacology, 2021
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li, Lan-ya Li, Yi-di Guan, Xi-sha Chen, Jin-ming Yang, Yan Cheng   +5 more
doaj   +1 more source

DNA damage, repair and aging

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2003
Oxidative DNA damage has been shown to accumulate with age in the nuclear and mitochondrial genome and cause cancer. Among DNA lesions produced by reactive oxygen species, base lesions and single-strand breaks are most frequently produced and cause mutation and cell death.
Akira, Yasui, Shin-ichiro, Kanno, Masashi, Takao   +2 more
openaire   +3 more sources

The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage

Cell Reports, 2014
Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew, Anne-Laure Pauleau, Natascha Steffen, Andrea Bergner, Peter B. Becker, Sylvia Erhardt   +5 more
doaj   +1 more source

Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression

BMC Complementary Medicine and Therapies, 2020
Background Flap Endonuclease 1(FEN1) has been considered as a new tumor marker in recent years and Jianpi Yangwei Decoction (JPYW) is a basic Traditional Chinese Medicine (TCM) for the treatment of gastric cancer.
Wenjie Huang, Huijuan Tang, Fang Wen, Xiaona Lu, Qingpei Li, Peng Shu   +5 more
doaj   +1 more source

From single-molecule to genome-wide mapping of DNA lesions: repair-assisted damage detection sequencing

Biophysical Reports, 2021
Mapping DNA damage and its repair has immense potential in understanding environmental exposures, their genotoxicity, and their impact on human health.
Noa Gilat, Dena Fridman, Hila Sharim, Sapir Margalit, Natalie R. Gassman, Yael Michaeli, Yuval Ebenstein   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +1 more source

DNA damage induced during mitosis undergoes DNA repair synthesis.

PLoS ONE, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Veronica Gomez Godinez, Sami Kabbara, Adria Sherman, Tao Wu, Shirli Cohen, Xiangduo Kong, Jose Luis Maravillas-Montero, Zhixia Shi, Daryl Preece, Kyoko Yokomori, Michael W Berns   +10 more
doaj   +1 more source

Repairing DNA damage in chromatin

Biochimie, 2003
Understanding how DNA repair processes occur in vivo when access to DNA is hindered by chromatin structural organisation is a current challenge. In general terms, the following sequence of events has to be considered within a chromatin environment: (i) finding a lesion (ii) repairing this lesion, and (iii) full restoration of a functional chromatin ...
Gontijo, A, Green, C, Almouzni, G
openaire   +2 more sources