Results 31 to 40 of about 377,653 (310)

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Nature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott   +12 more
doaj   +1 more source

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. [PDF]

, 2012
The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation.
Hilmar Strickfaden (148181), Guenther Dollinger, Brüning, Tino, Anja Derer, Judith Seel (148178), Volker Hable, Derer, Anja, Guido A Drexler, Burgdorf, Christian, Tino Brüning, Drexler, Guido A., Dollinger, Günther, Friedl, Anna A., Christoph Greubel, Greubel, Christoph, Thomas Cremer, Christian Burgdorf, Guido A. Drexler (148161), Christian Burgdorf (148169), Hable, Volker, Tino Brüning (148165), Hilmar Strickfaden, Judith Seel, Christoph Greubel (148173), Thomas Cremer (93), Günther Dollinger (148186), Anna A Friedl, Cremer, Thomas, Guido A. Drexler, Anna A. Friedl, Anja Derer (148175), Strickfaden, Hilmar, Günther Dollinger, Anna A. Friedl (148183), Seel, Judith, Volker Hable (148157)   +35 more
core   +1 more source

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2021
Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, Ping-Kun Zhou
doaj   +1 more source

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA

Cells, 2022
AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy.
Nathalie Berthault, Ptissam Bergam, Floriane Pereira, Pierre-Marie Girard, Marie Dutreix   +4 more
doaj   +1 more source

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]

, 2007
Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
core   +1 more source

Crystal structure of the UvrB dimer: insights into the nature and functioning of the UvrAB damage engagement and UvrB-DNA complexes [PDF]

, 2012
UvrB has a central role in the highly conserved UvrABC pathway functioning not only as a damage recognition element but also as an essential component of the lesion tracking machinery.
Jukes, R., Barrett, T, Bagnéris, C, Bagneris, Claire, Zamfir, V.S., Barrett, Tracey E., Zamfir, VS, Webster, MP, Jukes, R, Webster, Matthew P., Kay, Christopher W.M., Kay, CW   +11 more
core   +1 more source

Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. [PDF]

PLoS ONE, 2014
DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell death.
Pavan B Narayanaswamy, Mahshid Hodjat, Hermann Haller, Inna Dumler, Yulia Kiyan   +4 more
doaj   +1 more source

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]

, 2011
NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela, Bernd Baumann, Lisa Wiesmüller, Volcic, Meta, Fulda, Simone, Meta Volcic, Volcic, M., Wiesmueller, L., Baumann, B., Daniel, P., Sabine Karl, Simone Fulda, Daniela Salles, Peter Daniel, Karl, Sabine, Baumann, Bernd, Fulda, S., Salles, D., Karl, S., Daniel, Peter, Wiesmüller, Lisa   +20 more
core   +1 more source

BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury

Frontiers in Neuroscience, 2023
Emerging evidence suggests cellular senescence, as a consequence of excess DNA damage and deficient repair, to be a driver of brain dysfunction following repeated mild traumatic brain injury (rmTBI).
Emily Leung, Emily Leung, Daria Taskina, Nicole Schwab, Nicole Schwab, Lili-Naz Hazrati, Lili-Naz Hazrati   +6 more
doaj   +1 more source

DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]

, 2012
Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Koulintchenko Milana, Koulintchenko, Milana, Milana Koulintchenko, Sonya Vengrova, Vengrova S., Dalgaard Jacob Z., Trevor Eydmann, Prakash Arumugam, Eydmann Trevor, Koulintchenko M., Arumugam P., Vengrova, Sonya, Arumugam Prakash, Jacob Z. Dalgaard, Arumugam, Prakash, Eydmann T., Eydmann, Trevor, Dalgaard, Jacob Z., Jacob Z Dalgaard, Dalgaard J.Z., Vengrova Sonya   +20 more
core   +1 more source