Results 31 to 40 of about 343,462 (261)
Cells, 2022 AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy.
Nathalie Berthault +4 more
doaj +1 more source
DNA Damage, Repair, and Cancer Metabolism
Frontiers in Oncology, 2018 Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored.
Marc-Olivier Turgeon +3 more
doaj +1 more source
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2003 Oxidative DNA damage has been shown to accumulate with age in the nuclear and mitochondrial genome and cause cancer. Among DNA lesions produced by reactive oxygen species, base lesions and single-strand breaks are most frequently produced and cause mutation and cell death.
Akira, Yasui +2 more
openaire +3 more sources
The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage
Cell Reports, 2014 Summary: Chromatin reorganization and the incorporation of specific histone modifications during DNA damage response are essential steps for the successful repair of any DNA lesion.
Veena Mathew +5 more
doaj +1 more source
Biophysical Reports, 2021 Mapping DNA damage and its repair has immense potential in understanding environmental exposures, their genotoxicity, and their impact on human health.
Noa Gilat +6 more
doaj +1 more source
Frontiers in Neuroscience, 2023 Emerging evidence suggests cellular senescence, as a consequence of excess DNA damage and deficient repair, to be a driver of brain dysfunction following repeated mild traumatic brain injury (rmTBI).
Emily Leung +6 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
DNA Repair Pathways in Cancer Therapy and Resistance
Frontiers in Pharmacology, 2021 DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents.
Lan-ya Li +5 more
doaj +1 more source
Repairing DNA damage in chromatin
Biochimie, 2003 Understanding how DNA repair processes occur in vivo when access to DNA is hindered by chromatin structural organisation is a current challenge. In general terms, the following sequence of events has to be considered within a chromatin environment: (i) finding a lesion (ii) repairing this lesion, and (iii) full restoration of a functional chromatin ...
Gontijo, A, Green, C, Almouzni, G
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source