Results 21 to 30 of about 343,462 (261)
Histone post-translational modification and the DNA damage response
Genes and Diseases, 2023 DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently.
Haoyun Song +6 more
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Oxidative stress-induced DNA damage and repair in human peripheral blood mononuclear cells: protective role of hemoglobin. [PDF]
PLoS ONE, 2013 BACKGROUND:DNA repair is a cellular defence mechanism responding to DNA damage caused in large part by oxidative stress. There is a controversy with regard to the effect of red blood cells on DNA damage and cellular response.
Anat Gafter-Gvili +8 more
doaj +1 more source
H3K36me3, message from chromatin to DNA damage repair
Cell & Bioscience, 2020 Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage.
Zhongxing Sun +6 more
doaj +1 more source
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Aptamers for DNA Damage and Repair [PDF]
International Journal of Molecular Sciences, 2017 DNA is damaged on a daily basis, which can lead to heritable mutations and the activation of proto-oncogenes. Therefore, DNA damage and repair are critical risk factors in cancer, aging and disease, and are the underlying bases of most frontline cancer therapies.
openaire +4 more sources
Repair of radiation damage to DNA [PDF]
British Journal of Cancer, 2004 DNA double-strand breaks constitute the most dangerous type of DNA damage induced by ionising radiation (IR). Accordingly, the resistance of cells to IR is modulated by three intimately related cellular processes: DNA repair, recombination, and replication. Significant discoveries in this field of research have been made over the last few years.
Willers, H, Dahm-Daphi, J, Powell, S N
openaire +2 more sources
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2
Nature Communications, 2016 Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy +12 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, Ping-Kun Zhou
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DNA damage and repair following traumatic brain injury
Neurobiology of Disease, 2021 Traumatic brain injury (TBI) is known to promote significant DNA damage irrespective of age, sex, and species. Chemical as well as structural DNA modification start within minutes and persist for days after TBI.
Charles K. Davis, Raghu Vemuganti
doaj +1 more source
Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. [PDF]
PLoS ONE, 2014 DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell death.
Pavan B Narayanaswamy +4 more
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