Results 11 to 20 of about 377,653 (310)
DNA Damage, Repair, and Diseases [PDF]
BioMed Research International, 2002 DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it ...
Wiesmüller, Lisa +2 more
openaire +2 more sources
Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
Cell Reports, 2020 Summary: Cells deficient in ataxia telangiectasia mutated (ATM) are hypersensitive to ionizing radiation and other anti-cancer agents that induce double-strand DNA breaks. ATM inhibitors may therefore sensitize cancer cells to these agents.
Mu-Yan Cai +9 more
doaj +1 more source
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair
Life Science Alliance, 2021 Inhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as ...
Jingyi Tang, Patrick J Casey, Mei Wang
doaj +1 more source
Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
Cell Death and Disease, 2023 DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that metabolic pathways have been correlated with cellular response to DNA damage.
Seungyeon Yang +5 more
doaj +1 more source
eLife, 2019 Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot +5 more
doaj +1 more source
DNA Damage Atlas: an atlas of DNA damage and repair
Nucleic Acids Research, 2023 Abstract DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide profiling approaches have been developed to monitor DNA damage and repair events ...
Yu Liang +9 more
openaire +2 more sources
REPAIRtoire--a database of DNA repair pathways. [PDF]
, 2010 REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian +17 more
core +1 more source
eLife, 2018 TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus act
Matthew Day +5 more
doaj +1 more source
Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures
DNA, 2022 Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can
Tonia T. Li, Karen M. Vasquez
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Frontiers in Oncology, 2022 Cells experience both endogenous and exogenous DNA damage daily. To maintain genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a series of repair functions, termed DNA damage response (DDR), to repair DNA damage and ...
Huimin Lei +7 more
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