Results 11 to 20 of about 362,053 (261)
DNA Damage, Mutagenesis, and DNA Repair [PDF]
Journal of Nucleic Acids, 2010 This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to ...
Ashis Basu +3 more
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Nature, 2003 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury.
Michaela Cichon +2 more
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DNA Repair by Reversal of DNA Damage [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to ...
Chengqi, Yi, Chuan, He
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PTEN in DNA damage repair [PDF]
Cancer Letters, 2012 The ability of DNA repair in a cell is vital to its genomic integrity and thus to the normal functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established tumor suppressor gene that induces apoptosis and controls cell growth by inhibiting the PI3K/AKT pathway.
Mei, Ming, Yu-Ying, He
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Radiobiology Summaries: DNA Damage and Repair [PDF]
Clinical Oncology, 2021 No abstract available.
Chalmers, A.J., Carruthers, R.D.
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DNA damage and repair in atherosclerosis [PDF]
Cardiovascular Research, 2006 There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair.
Mahmoudi, M., Mercer, J., Bennett, M.
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DNA Damage, Repair, and Diseases [PDF]
BioMed Research International, 2002 DNA is the essential carrier of genetic information in all living cells. How is the huge amount of DNA in organisms from bacteria to humans maintained and protected from the ravages of noxious agents in the environment? The chemical stability of the DNA molecule is not unusually great, DNA undergoes several types of spontaneous modifications, and it ...
Wiesmüller, Lisa +2 more
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DNA Damage Atlas: an atlas of DNA damage and repair
Nucleic Acids Research, 2023 Abstract DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide profiling approaches have been developed to monitor DNA damage and repair events ...
Yu Liang +9 more
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Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures
DNA, 2022 Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can
Tonia T. Li, Karen M. Vasquez
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Cell Reports, 2015 53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other
Robert A. Baldock +7 more
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