Results 41 to 50 of about 1,044,115 (187)
Nitric Oxide: Genomic Instability And Synthetic Lethality
Redox Biology, 2015 Regardless of etiology, inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide and reactive nitrogen species (NO/RNS) in epithelial and inflammatory cells at the site of ...
Vasily A. Yakovlev
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Synthetic Lethal Interactions of RECQ Helicases
Trends in Cancer, 2021 DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in chromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in DNA repair, the replication stress response, and/or transcriptional activation.
Arindam, Datta +3 more
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Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics
Journal of Integrative Bioinformatics, 2017 The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer.
Benstead-Hume Graeme +2 more
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Disease Models & Mechanisms, 2012 The post-genomic era is marked by a pressing need to functionally characterize genes through understanding gene-gene interactions, as well as interactions between biological pathways.
Vinita A. Hajeri, James F. Amatruda
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Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]
, 2011 Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Moreno, Eduardo, Eduardo Moreno
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THE PROBLEM OF SYNTHETIC LETHALS IN DROSOPHILA MELANOGASTER [PDF]
Genetics, 1956 Uploaded by Plazi for TaxoDros. We do not have abstracts.
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Genetic mapping and predictive modeling of paralog synthetic lethality
Cell ReportsSummary: Paralogs are abundant in the human genome and thought to be a primary source of synthetic lethality, yet the vast paralogome remains largely uncharacterized. A digenic screen of 36,648 paralogous pairs in the human genome revealed that synthetic
Michael J. Flister +7 more
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Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
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Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
Briefings in BioinformaticsAbstract Synthetic lethality (SL) has shown great promise for the discovery of novel targets in cancer. CRISPR double-knockout (CDKO) technologies can only screen several hundred genes and their combinations, but not genome-wide. Therefore, good SL prediction models are highly needed for genes and gene pairs selection in CDKO experiments.
Kunjie Fan +7 more
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Rapid Inhibitor Discovery by Exploiting Synthetic Lethality
, 2022 Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery.
Aaron Mychack (2614525) +23 more
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