Results 41 to 50 of about 43,707 (255)
SLKB: synthetic lethality knowledge base
Nucleic Acids Research, 2023 Abstract Emerging CRISPR–Cas9 technology permits synthetic lethality (SL) screening of large number of gene pairs from gene combination double knockout (CDKO) experiments. However, the poor integration and annotation of CDKO SL data in current SL databases limit their utility, and diverse methods of calculating SL scores prohibit their ...
Birkan Gökbağ +6 more
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RAD52: Paradigm of Synthetic Lethality and New Developments
Frontiers in Genetics, 2021 DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA damage that cause genomic instability that lead to cancer development.
Matthew J. Rossi +3 more
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Synthetic Lethal Vulnerabilities of Cancer
Annual Review of Pharmacology and Toxicology, 2015 The great majority of targeted anticancer drugs inhibit mutated oncogenes that display increased activity. Yet many tumors do not contain such actionable aberrations, such as those harboring loss-of-function mutations. The notion of targeting synthetic lethal vulnerabilities in cancer cells has provided an alternative approach to exploiting more of ...
Ferran Fece de la Cruz +2 more
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Frontiers in OncologyWith the tremendous success of the PARP inhibitor olaparib in clinical practice, synthetic lethality has become an important field for the discovery and development of anticancer drugs.
Xiaoliang Gong +4 more
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Targeting synthetic lethal paralogs in cancer
Trends in Cancer, 2023 Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for the development of targeted therapeutics in cancer. Pairs of duplicate genes (paralogs) often share common functionality and hence are a potentially rich source of synthetic lethal interactions.
Colm J. Ryan +3 more
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Nitric Oxide: Genomic Instability And Synthetic Lethality
Redox Biology, 2015 Regardless of etiology, inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide and reactive nitrogen species (NO/RNS) in epithelial and inflammatory cells at the site of ...
Vasily A. Yakovlev
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PARP inhibitors: Synthetic lethality in the clinic [PDF]
Science, 2017 PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a century ago. Tumors arising in patients who carry germline mutations in either BRCA1 or
Christopher J. Lord, Alan Ashworth
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Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics
Journal of Integrative Bioinformatics, 2017 The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer.
Benstead-Hume Graeme +2 more
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Disease Models & Mechanisms, 2012 The post-genomic era is marked by a pressing need to functionally characterize genes through understanding gene-gene interactions, as well as interactions between biological pathways.
Vinita A. Hajeri, James F. Amatruda
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source