Results 21 to 30 of about 1,044,115 (187)
Synthetic lethality and the minimal genome size problem
mSphereGene knockout studies suggest that ~300 genes in a bacterial genome and ~1,100 genes in a yeast genome cannot be deleted without loss of viability. These single-gene knockout experiments do not account for negative genetic interactions, when two or more ...
Sara Rahiminejad +3 more
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Synthetic Lethality in Ovarian Cancer [PDF]
Molecular Cancer Therapeutics, 2021 AbstractOvarian cancers include several distinct malignancies which differ with respect to clinicopathologic features and prognosis. High-grade serous cancer is the most common histologic subtype and accounts for most ovarian cancer–related deaths. High-grade serous ovarian cancer (HGSOC) is treated with surgery and platinum-based chemotherapy, but ...
Akshaya Chandrasekaran, Kevin M. Elias
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Paralog-based synthetic lethality: rationales and applications
Frontiers in Oncology, 2023 Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL) offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair can be specifically targeted by disrupting the function of the other genes,
Yucui Xin, Yingsheng Zhang
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Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
Journal of Hematology & Oncology, 2020 Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the
Win Topatana +10 more
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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
Communications Biology, 2021 Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation.
Ilirjana Bajrami +11 more
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DNA repair and synthetic lethality [PDF]
International Journal of Oral Science, 2011 Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability
Guo, Gong-she +5 more
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Nature Nanotechnology, 2017 Nanoparticles loaded with paclitaxel and nintedanib induce synthetic lethality in endometrial cancer cells.
Rolfo, Christian, Giovannetti, Elisa
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The Population Genetics of Synthetic Lethals [PDF]
Genetics, 1998 Abstract Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial.
P C, Phillips, N A, Johnson
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Cell Death Discovery, 2022 Many genes responsible for Malignant mesothelioma (MM) have been identified as tumor suppressor genes and it is difficult to target these genes directly at a molecular level.
Koya Suzuki +14 more
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Center on Survivability and Lethality CSL Home [PDF]
, 2015 Includes an image of the main page on this date and compressed file containing additional web pages.The Center for Survivability and Lethality research and education enterprise is the first interdisciplinary center dedicated to making the broad range of
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