Results 21 to 30 of about 1,092,864 (243)

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Journal of Hematology & Oncology, 2020
Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the
Win Topatana, Sarun Juengpanich, Shijie Li, Jiasheng Cao, Jiahao Hu, Jiyoung Lee, Kenneth Suliyanto, Diana Ma, Bin Zhang, Mingyu Chen, Xiujun Cai   +10 more
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Synthetic lethality between TP53 and ENDOD1

Nature Communications, 2022
The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die.
Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M. Carr, Cong Liu   +11 more
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Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors [PDF]

, 2017
In BRCA2-defective cells, poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors can trigger synthetic lethality, as two independent DNA-repairing mechanisms are simultaneously impaired. Here, we have pharmacologically induced synthetic lethality,
Minucci S., Robertson J., Masini T., Rossini L., Boutard N., Roberti M., Manerba M., Di Stefano G., Farabegoli F., Pallavicini I., Giacomini E., Cavalli A., Falchi F., Pellicciari R., Di Ianni L.   +14 more
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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Communications Biology, 2021
Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation.
Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord   +11 more
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Breast Cancer Predisposition Genes and Synthetic Lethality

, 2021
BRCA1 and BRCA2 are tumor suppressor genes with pivotal roles in the development of breast and ovarian cancers. These genes are essential for DNA double-strand break repair via homologous recombination (HR), which is a virtually error-free DNA repair ...
Hannah E. Neiger, Emily L. Siegler, Yihui Shi   +2 more
core   +1 more source

Protocol for Comprehensive Synthetic Lethality Screens

STAR Protocols, 2020
Summary: Here, we provide a detailed protocol for synthetic lethality screens in a Jurkat T cell leukemia line using cell death as the readout measuring the combinatorial effect of a pan-PI3K inhibitor (GDC0941) with specific gene depletion by shRNA.
Damia Romero-Moya, Jeroen P. Roose
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SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma

Cell Death Discovery, 2022
Many genes responsible for Malignant mesothelioma (MM) have been identified as tumor suppressor genes and it is difficult to target these genes directly at a molecular level.
Koya Suzuki, Masaki Tange, Ryota Yamagishi, Hiroyuki Hanada, Satomi Mukai, Tatsuhiro Sato, Takeshi Tanaka, Tomohiro Akashi, Kenji Kadomatsu, Tohru Maeda, Takashi Miida, Ichiro Takeuchi, Hiroshi Murakami, Yoshitaka Sekido, Yuko Murakami-Tonami   +14 more
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Overview of Ferroptosis and Synthetic Lethality Strategies

, 2021
Ferroptosis, a term first proposed in 2012, is iron-dependent, non-apoptotic regulatory cell death induced by erastin. Ferroptosis was originally discovered during synthetic lethal screening for drugs sensitive to RAS mutant cells, and is closely related
Susumu Kirimura, Kouhei Yamamoto, Towako Taguchi, Masanobu Kitagawa, Yuko Kinowaki, Iichiroh Onishi   +5 more
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Modeling synthetic lethality [PDF]

, 2008
International audienceBACKGROUND: Synthetic lethality defines a genetic interaction where the combination of mutations in two or more genes leads to cell death.
Nolwenn Le Meur, Gentleman, Robert, Le Meur, Nolwenn, Robert Gentleman   +3 more
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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Acta Pharmaceutica Sinica B, 2020
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic
Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, Yifan Liu, Changjie Wu, Lakhansing Pardeshi, Kaeling Tan, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim   +10 more
doaj   +1 more source