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Synthetic Lethality in Ovarian Cancer [PDF]
Molecular Cancer Therapeutics, 2021 AbstractOvarian cancers include several distinct malignancies which differ with respect to clinicopathologic features and prognosis. High-grade serous cancer is the most common histologic subtype and accounts for most ovarian cancer–related deaths. High-grade serous ovarian cancer (HGSOC) is treated with surgery and platinum-based chemotherapy, but ...
Akshaya Chandrasekaran, Kevin M. Elias
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Research progress for the development of anti-tumor drugs based on synthetic lethality
生物医学转化, 2022 Synthetic lethality describes a phenomenon where mutation of any one of two non-lethal genes does not affect cell survival, whereas mutation of both genes significantly compromise cell viability.
Chen Pei +3 more
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BMC Cancer, 2023 Background Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells.
Shane O’Brien +8 more
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The role of protein interactions in mediating essentiality and synthetic lethality. [PDF]
PLoS ONE, 2013 Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these "essential genes" play a central role in biological function.
David Talavera +2 more
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Modeling synthetic lethality [PDF]
Genome Biology, 2008 Abstract Background Synthetic lethality defines a genetic interaction where the combination of mutations in two or more genes leads to cell death. The implications of synthetic lethal screens have been discussed in the context of drug development as synthetic lethal pairs could be used to ...
Le Meur, Nolwenn, Gentleman, Robert
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Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. [PDF]
PLoS Computational Biology, 2015 Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously.
Alexandra Jacunski +2 more
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Paralog-based synthetic lethality: rationales and applications
Frontiers in Oncology, 2023 Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL) offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair can be specifically targeted by disrupting the function of the other genes,
Yucui Xin, Yingsheng Zhang
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Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
Journal of Hematology & Oncology, 2020 Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the
Win Topatana +10 more
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Synthetic Lethality Targeting Polθ
Genes, 2022 Research studies regarding synthetic lethality (SL) in human cells are primarily motivated by the potential of this phenomenon to be an effective, but at the same time, safe to the patient’s anti-cancer chemotherapy. Among the factors that are targets for the induction of the synthetic lethality effect, those involved in DNA repair seem to be the most ...
Małgorzata Drzewiecka +4 more
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Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
Communications Biology, 2021 Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation.
Ilirjana Bajrami +11 more
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