Results 11 to 20 of about 1,770,471 (326)
Targeting synthetic lethality in colorectal cancer [PDF]
Chinese Medical JournalPingting Chen +6 more
doaj +4 more sources
DNA repair and synthetic lethality [PDF]
International Journal of Oral Science, 2011 Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR ...
Delsite, Robert +5 more
core +6 more sources
Protocol for Comprehensive Synthetic Lethality Screens
STAR Protocols, 2020 Summary: Here, we provide a detailed protocol for synthetic lethality screens in a Jurkat T cell leukemia line using cell death as the readout measuring the combinatorial effect of a pan-PI3K inhibitor (GDC0941) with specific gene depletion by shRNA.
Damia Romero-Moya, Jeroen P. Roose
doaj +5 more sources
SLKB: synthetic lethality knowledge base
Nucleic Acids Research, 2023 Emerging CRISPR–Cas9 technology permits synthetic lethality (SL) screening of large number of gene pairs from gene combination double knockout (CDKO) experiments.
Birkan Gökbağ +6 more
semanticscholar +3 more sources
Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
Briefings in BioinformaticsSynthetic lethality (SL) has shown great promise for the discovery of novel targets in cancer. CRISPR double-knockout (CDKO) technologies can only screen several hundred genes and their combinations, but not genome-wide.
Kunjie Fan +7 more
semanticscholar +3 more sources
Synthetic lethality between TP53 and ENDOD1 [PDF]
Nature Communications, 2022 The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die.
Zizhi Tang +11 more
doaj +3 more sources
Synthetic Lethality Targeting Polθ
Genes, 2022 Research studies regarding synthetic lethality (SL) in human cells are primarily motivated by the potential of this phenomenon to be an effective, but at the same time, safe to the patient’s anti-cancer chemotherapy.
M. Drzewiecka +4 more
semanticscholar +3 more sources
Synthetic Lethality in Ovarian Cancer [PDF]
Molecular Cancer Therapeutics, 2021 Ovarian cancers include several distinct malignancies which differ with respect to clinicopathologic features and prognosis. High-grade serous cancer is the most common histologic subtype and accounts for most ovarian cancer–related deaths.
Akshaya Chandrasekaran, K. Elias
semanticscholar +3 more sources
Protease addiction and synthetic lethality in cancer [PDF]
Frontiers in Oncology, 2011 The oncogene addiction concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed phenotype, while the term non-oncogene addiction has been introduced to define the exacerbated necessity of the ...
Jose M.P. Freije +2 more
doaj +3 more sources
Prediction of lethal and synthetically lethal knock-outs in regulatory networks [PDF]
Theory in Biosciences, 2013 The complex interactions involved in regulation of a cell's function are captured by its interaction graph. More often than not, detailed knowledge about enhancing or suppressive regulatory influences and cooperative effects is lacking and merely the ...
A Inger +28 more
core +3 more sources