Results 11 to 20 of about 43,707 (255)
Targeting synthetic lethality in colorectal cancer [PDF]
Chinese Medical JournalPingting Chen +6 more
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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Acta Pharmaceutica Sinica B, 2021 Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li +7 more
doaj +3 more sources
The tumor therapy landscape of synthetic lethality [PDF]
Nature Communications, 2021 Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http:/
Biyu Zhang +11 more
doaj +3 more sources
Protocol for Comprehensive Synthetic Lethality Screens
STAR Protocols, 2020 Summary: Here, we provide a detailed protocol for synthetic lethality screens in a Jurkat T cell leukemia line using cell death as the readout measuring the combinatorial effect of a pan-PI3K inhibitor (GDC0941) with specific gene depletion by shRNA.
Damia Romero-Moya, Jeroen P. Roose
doaj +5 more sources
Synthetic lethality between TP53 and ENDOD1 [PDF]
Nature Communications, 2022 The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die.
Zizhi Tang +11 more
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Protease addiction and synthetic lethality in cancer [PDF]
Frontiers in Oncology, 2011 The oncogene addiction concept refers to the dependence of cancer cells on the function of the oncogenes responsible for their transformed phenotype, while the term non-oncogene addiction has been introduced to define the exacerbated necessity of the ...
Jose M.P. Freije +2 more
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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Cell Reports, 2016 ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance ...
Kumar Sanjiv +14 more
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Synthetic lethality in cancer: mechanism exploration and therapeutic applications [PDF]
Cell Communication and SignalingSynthetic lethality (SL) is a genetic interaction phenomenon in which a cell can survive when either of two genes is individually mutated, but simultaneous disruption of both genes leads to cell death.
Pusong Zhao +5 more
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Genome‐scale gene/reaction essentiality and synthetic lethality analysis
Molecular Systems Biology, 2009 Synthetic lethals are to pairs of non‐essential genes whose simultaneous deletion prohibits growth. One can extend the concept of synthetic lethality by considering gene groups of increasing size where only the simultaneous elimination of all genes is ...
Patrick F Suthers +2 more
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MGANSL: multi-network representation generating with generative adversarial network for synthetic lethality prediction [PDF]
BMC BioinformaticsBackground: Cancer is a complex disease that arises from the simultaneous mutations of multiple biological molecules. An effective therapeutic strategy is to exploit synthetic lethality (SL) by targeting the SL partner of cancer driver genes ...
Jinxin Li +5 more
doaj +2 more sources