Results 11 to 20 of about 1,092,864 (243)

Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. [PDF]

PLoS Computational Biology, 2015
Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously.
Alexandra Jacunski, Scott J Dixon, Nicholas P Tatonetti   +2 more
doaj   +2 more sources

Synthetic Lethality Approaches in Acute Lymphoblastic Leukemia

Hemato, 2023
Acute lymphoblastic leukemia (ALL), a remarkable cancer that mainly affects children, has seen commendable advances in its treatment. However, the occurrence of relapses after initial treatments poses a major threat and is one of the leading causes of ...
Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia   +1 more
doaj   +2 more sources

Anti-angiogenesis therapy, synthetic lethality, and checkpoint inhibition in ovarian cancer: state of the science and novel combinations [PDF]

Drugs in Context, 2018
Over the last decade, new therapeutics in the form of anti-angiogenic treatment, synthetic lethality, and checkpoint inhibition have offered new options for the treatment of ovarian cancer.
Marisa C Liu, Krishnansu S Tewari
doaj   +2 more sources

Advances in synthetic lethality modalities for glioblastoma multiforme

Open Medicine
Glioblastoma multiforme (GBM) is characterized by a high mortality rate, high resistance to cytotoxic chemotherapy, and radiotherapy due to its highly aggressive nature.
Richard Seidu A.
doaj   +2 more sources

Application and research progress of synthetic lethality in the development of anticancer therapeutic drugs [PDF]

Frontiers in Oncology
With the tremendous success of the PARP inhibitor olaparib in clinical practice, synthetic lethality has become an important field for the discovery and development of anticancer drugs.
Xiaoliang Gong, Chunxi Liu, Haoyang Tang, Song Wu, Qingyun Yang   +4 more
doaj   +2 more sources

Supplementary data from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

, 2021
Supplementary data from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in ...
Theodoros I. Roumeliotis (1725436), Geneviève Almouzni (14952607), Jessica A. Downs (14952613), Sophie Postel-Vinay (14946771), Suzanna R. Hopkins (14952583), Clémence Hénon (14952589), Raphaël Margueron (14952604), Asha Konde (1808494), Eric Deutsch (14952610), Christophe Massard (14952598), Thomas Eychenne (14952565), Jean-Charles Soria (66947), Stephen J. Pettitt (14952601), Léo Colmet-Daage (14952568), Nicolas Dorvault (3585098), Roman M. Chabanon (14952562), Christopher J. Lord (14952616), Cornelia Meisenberg (14952574), Elaine Del Nery (310455), Carine Ngo (14952580), Jyoti S. Choudhary (9927836), Marlène Garrido (14952571), Samuel Jouny (14952586), Andrew Lamb (14952577), Ilirjana Bajrami (407000), Clémence Astier (14952595), Asuka Kawai-Kawachi (14952592), Daphné Morel (5330492)   +27 more
core   +5 more sources

Synthetic Lethality Targeting Polθ [PDF]

, 2022
Research studies regarding synthetic lethality (SL) in human cells are primarily motivated by the potential of this phenomenon to be an effective, but at the same time, safe to the patient’s anti-cancer chemotherapy.
Gabriela Barszczewska-Pietraszek, Tomasz Skorski, Drzewiecka, Małgorzata, Skorski, Tomasz, Czarny, Piotr, Barszczewska-Pietraszek, Gabriela, Małgorzata Drzewiecka, Tomasz Śliwiński, Śliwiński, Tomasz, Piotr Czarny   +9 more
core   +1 more source

Supplementary Figure from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

, 2021
Supplementary Figure from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in ...
Theodoros I. Roumeliotis (1725436), Geneviève Almouzni (14952607), Jessica A. Downs (14952613), Sophie Postel-Vinay (14946771), Suzanna R. Hopkins (14952583), Clémence Hénon (14952589), Raphaël Margueron (14952604), Asha Konde (1808494), Eric Deutsch (14952610), Christophe Massard (14952598), Thomas Eychenne (14952565), Jean-Charles Soria (66947), Stephen J. Pettitt (14952601), Léo Colmet-Daage (14952568), Nicolas Dorvault (3585098), Roman M. Chabanon (14952562), Christopher J. Lord (14952616), Cornelia Meisenberg (14952574), Elaine Del Nery (310455), Carine Ngo (14952580), Jyoti S. Choudhary (9927836), Marlène Garrido (14952571), Samuel Jouny (14952586), Andrew Lamb (14952577), Ilirjana Bajrami (407000), Clémence Astier (14952595), Asuka Kawai-Kawachi (14952592), Daphné Morel (5330492)   +27 more
core   +3 more sources

The role of protein interactions in mediating essentiality and synthetic lethality. [PDF]

PLoS ONE, 2013
Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these "essential genes" play a central role in biological function.
David Talavera, David L Robertson, Simon C Lovell   +2 more
doaj   +1 more source

Paralog-based synthetic lethality: rationales and applications

Frontiers in Oncology, 2023
Tumor cells can result from gene mutations and over-expression. Synthetic lethality (SL) offers a desirable setting where cancer cells bearing one mutated gene of an SL gene pair can be specifically targeted by disrupting the function of the other genes,
Yucui Xin, Yingsheng Zhang
doaj   +1 more source