Results 31 to 40 of about 1,044,115 (187)
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors [PDF]
, 2017 In BRCA2-defective cells, poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitors can trigger synthetic lethality, as two independent DNA-repairing mechanisms are simultaneously impaired. Here, we have pharmacologically induced synthetic lethality,
Farabegoli, Fulvia +29 more
core +3 more sources
Center on Survivability and Lethality (CSL) Research Faculty [PDF]
, 2013 NPS has a strong history in teaching and research in aircraft survivability and air defense lethality. On Jan. 30, the Naval Postgraduate School (NPS) announced the creation of the Center for Survivability and Lethality.
core +2 more sources
SSLPRED: PREDICTING SYNTHETIC SICKNESS LETHALITY [PDF]
Biocomputing 2012, 2011 Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes.
Nirmalya Bandyopadhyay +2 more
openaire +3 more sources
SLKB: synthetic lethality knowledge base
Nucleic Acids Research, 2023 Abstract Emerging CRISPR–Cas9 technology permits synthetic lethality (SL) screening of large number of gene pairs from gene combination double knockout (CDKO) experiments. However, the poor integration and annotation of CDKO SL data in current SL databases limit their utility, and diverse methods of calculating SL scores prohibit their ...
Birkan Gökbağ +6 more
openaire +2 more sources
Acta Pharmaceutica Sinica B, 2020 Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic
Baoyuan Zhang +10 more
doaj +1 more source
mBio, 2023 Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb).
Yuanyuan Xu +3 more
doaj +1 more source
Synthetic Lethal Vulnerabilities of Cancer
Annual Review of Pharmacology and Toxicology, 2015 The great majority of targeted anticancer drugs inhibit mutated oncogenes that display increased activity. Yet many tumors do not contain such actionable aberrations, such as those harboring loss-of-function mutations. The notion of targeting synthetic lethal vulnerabilities in cancer cells has provided an alternative approach to exploiting more of ...
Ferran Fece de la Cruz +2 more
openaire +3 more sources
RAD52: Paradigm of Synthetic Lethality and New Developments
Frontiers in Genetics, 2021 DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA damage that cause genomic instability that lead to cancer development.
Matthew J. Rossi +3 more
doaj +1 more source
Evolving DNA repair synthetic lethality targets in cancer [PDF]
, 2022 DNA damage signaling response and repair (DDR) is a critical defense mechanism against genomic instability. Impaired DNA repair capacity is an important risk factor for cancer development.
Jeyapalan, Jennie N +7 more
core +1 more source
Targeting synthetic lethal paralogs in cancer
Trends in Cancer, 2023 Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for the development of targeted therapeutics in cancer. Pairs of duplicate genes (paralogs) often share common functionality and hence are a potentially rich source of synthetic lethal interactions.
Colm J. Ryan +3 more
openaire +2 more sources