Results 31 to 40 of about 1,092,864 (243)

Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

, 2021
Supplementary Table from PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in ...
Theodoros I. Roumeliotis (1725436), Geneviève Almouzni (14952607), Jessica A. Downs (14952613), Sophie Postel-Vinay (14946771), Suzanna R. Hopkins (14952583), Clémence Hénon (14952589), Raphaël Margueron (14952604), Asha Konde (1808494), Eric Deutsch (14952610), Christophe Massard (14952598), Thomas Eychenne (14952565), Jean-Charles Soria (66947), Stephen J. Pettitt (14952601), Léo Colmet-Daage (14952568), Nicolas Dorvault (3585098), Roman M. Chabanon (14952562), Christopher J. Lord (14952616), Cornelia Meisenberg (14952574), Elaine Del Nery (310455), Carine Ngo (14952580), Jyoti S. Choudhary (9927836), Marlène Garrido (14952571), Samuel Jouny (14952586), Andrew Lamb (14952577), Ilirjana Bajrami (407000), Clémence Astier (14952595), Asuka Kawai-Kawachi (14952592), Daphné Morel (5330492)   +27 more
core   +1 more source

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

mBio, 2023
Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb).
Yuanyuan Xu, Sabine Ehrt, Dirk Schnappinger, Tiago Beites   +3 more
doaj   +1 more source

RAD52: Paradigm of Synthetic Lethality and New Developments

Frontiers in Genetics, 2021
DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA damage that cause genomic instability that lead to cancer development.
Matthew J. Rossi, Sarah F. DiDomenico, Mikir Patel, Alexander V. Mazin   +3 more
doaj   +1 more source

Cancer. Potential of the synthetic lethality principle.

, 2016
Elucidating the first principles of synthetic lethality in cancer, including biological context, will assist clinical ...

core   +1 more source

Supplementary Figure from Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

, 2022
Supplementary Figure from Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous ...
Dmitriy Zamarin (14955513), Kaitlin P. Zawacki (9024218), Goutham Narla (2805529), Fallon K. Noto (9470834), Arathi Mohan (14955510), Kathryn M. Miller (14955495), Tahra K. Suhan (14955504), Jaya Sangodkar (9470837), Lauren Hurst (14955498), Terrance J. Haanen (14955501), Jonida Trako (14955507), Caitlin M. O'Connor (14937206), Sarah E. Taylor (14955492), Analisa DiFeo (14937230)   +13 more
core   +1 more source

Supplementary Data from Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

, 2022
Supplementary Data from Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in ...
Hongxia Zhang (14957673), Yingfei Wang (10648653), Weibo Luo (14941257), Lei Bao (9883), Yijie Wang (90004), Kimmo J. Hatanpaa (10648647), Hui Peng (14957670), Bo Zhang (6559), Mi Zhou (9884), Yan Chen (4308), Chenliang Wang (14941239), Jennifer E. Wang (14941245), Feng Cai (453757), Yanling Niu (7135010), Ralph J. DeBerardinis (9224285), John A. Copland (248788)   +15 more
core   +1 more source

Nitric Oxide: Genomic Instability And Synthetic Lethality

Redox Biology, 2015
Regardless of etiology, inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide and reactive nitrogen species (NO/RNS) in epithelial and inflammatory cells at the site of ...
Vasily A. Yakovlev
doaj   +1 more source

Supplementary Table from Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma

, 2022
Supplementary Table from Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous ...
Kaitlin P. Zawacki (9024218), Fallon K. Noto (9470834), Fallon K. Noto, Arathi Mohan, Goutham Narla, Arathi Mohan (14955510), Tahra K. Suhan (14955504), Sarah E. Taylor, Dmitriy Zamarin, Jaya Sangodkar (9470837), Terrance J. Haanen, Jaya Sangodkar, Jonida Trako (14955507), Sarah E. Taylor (14955492), Dmitriy Zamarin (14955513), Kathryn M. Miller, Jonida Trako, Goutham Narla (2805529), Caitlin M. O'Connor, Tahra K. Suhan, Kathryn M. Miller (14955495), Lauren Hurst (14955498), Terrance J. Haanen (14955501), Kaitlin P. Zawacki, Analisa DiFeo, Caitlin M. O'Connor (14937206), Lauren Hurst, Analisa DiFeo (14937230)   +27 more
core   +1 more source

Computational Approaches to Identify Genetic Interactions for Cancer Therapeutics

Journal of Integrative Bioinformatics, 2017
The development of improved cancer therapies is frequently cited as an urgent unmet medical need. Here we describe how genetic interactions are being therapeutically exploited to identify novel targeted treatments for cancer.
Benstead-Hume Graeme, Wooller Sarah K., Pearl Frances M.G.   +2 more
doaj   +1 more source

Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

Disease Models & Mechanisms, 2012
The post-genomic era is marked by a pressing need to functionally characterize genes through understanding gene-gene interactions, as well as interactions between biological pathways.
Vinita A. Hajeri, James F. Amatruda
doaj   +1 more source