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The Population Genetics of Synthetic Lethals [PDF]
Genetics, 1998 Abstract Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial.
P C, Phillips, N A, Johnson
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DNA repair and synthetic lethality [PDF]
International Journal of Oral Science, 2011 Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability
Guo, Gong-she +5 more
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Synthetic Lethality Approaches in Acute Lymphoblastic Leukemia
Hemato, 2023 Acute lymphoblastic leukemia (ALL), a remarkable cancer that mainly affects children, has seen commendable advances in its treatment. However, the occurrence of relapses after initial treatments poses a major threat and is one of the leading causes of ...
Francisco Alejandro Lagunas-Rangel +1 more
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Nature Nanotechnology, 2017 Nanoparticles loaded with paclitaxel and nintedanib induce synthetic lethality in endometrial cancer cells.
Rolfo, Christian, Giovannetti, Elisa
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Cell Death Discovery, 2022 Many genes responsible for Malignant mesothelioma (MM) have been identified as tumor suppressor genes and it is difficult to target these genes directly at a molecular level.
Koya Suzuki +14 more
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Overview of Ferroptosis and Synthetic Lethality Strategies [PDF]
International Journal of Molecular Sciences, 2021 Ferroptosis, a term first proposed in 2012, is iron-dependent, non-apoptotic regulatory cell death induced by erastin. Ferroptosis was originally discovered during synthetic lethal screening for drugs sensitive to RAS mutant cells, and is closely related to synthetic lethality. Ferroptosis sensitizes cancer stem cells and tumors that undergo epithelial−
Yuko Kinowaki +5 more
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SSLPRED: PREDICTING SYNTHETIC SICKNESS LETHALITY [PDF]
Biocomputing 2012, 2011 Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes.
Nirmalya Bandyopadhyay +2 more
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Synthetic Lethal Interactions of RECQ Helicases
Trends in Cancer, 2021 DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in chromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in DNA repair, the replication stress response, and/or transcriptional activation.
Arindam, Datta +3 more
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Acta Pharmaceutica Sinica B, 2020 Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic
Baoyuan Zhang +10 more
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mBio, 2023 Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb).
Yuanyuan Xu +3 more
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