Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma
Cancer Research, 2022 Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth.
Bo Zhang +15 more
semanticscholar +1 more source
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
SSLPRED: PREDICTING SYNTHETIC SICKNESS LETHALITY [PDF]
Biocomputing 2012, 2011 Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes.
Nirmalya Bandyopadhyay +2 more
openaire +2 more sources
Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. [PDF]
, 2011 Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively.
Elenore S. Bogoch, Samuel Bogoch
core +2 more sources
bioRxiv, 2021 Two genes are synthetic lethal if mutations in both genes result in impaired cell viability, while mutation of either gene does not affect the cell survival.
Jie Wang +6 more
semanticscholar +1 more source
Synthetic Lethal Interactions of RECQ Helicases
Trends in Cancer, 2021 DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in chromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in DNA repair, the replication stress response, and/or transcriptional activation.
Arindam, Datta +3 more
openaire +3 more sources
KG4SL: knowledge graph neural network for synthetic lethality prediction in human cancers
Bioinform., 2021 Motivation Synthetic lethality (SL) is a promising gold mine for the discovery of anti-cancer drug targets. Wet-lab screening of SL pairs is afflicted with high cost, batch-effect, and off-target problems.
Shike Wang +7 more
semanticscholar +1 more source
Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]
, 2008 Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami +3 more
core +4 more sources
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Journal of Biomedical Sciences, 2022 Chromatin remodeling is an essential cellular process for organizing chromatin structure into either open or close configuration at specific chromatin locations by orchestrating and modifying histone complexes.
Jayaprakash Mandal +3 more
semanticscholar +1 more source
Marked Rise in Replikin Counts in H5N1 Influenza Virus Localized to Lethality Gene p B1. [PDF]
, 2011 : Virus outbreaks have been found to be related to the concentration of a new class of genomic peptides, Replikins^1^. The eight genes of H5N1 influenza virus were analyzed for the distribution of Replikin Counts (number Replikins /100 amino acids) in 2 ...
Elenore S. Bogoch, Samuel Bogoch
core +2 more sources