Results 51 to 60 of about 1,044,115 (187)
Frontiers in Bioengineering and Biotechnology, 2022 Background: Drugs based on synthetic lethality have advantages such as inhibiting tumor growth and affecting normal tissue in vivo. However, specific targets for osteosarcoma have not been acknowledged yet.
Haoran Mu +18 more
doaj +1 more source
Cancer. Potential of the synthetic lethality principle.
, 2013 Elucidating the first principles of synthetic lethality in cancer, including biological context, will assist clinical ...
Nijman, Sebastian +2 more
core +1 more source
Prediction of lethal and synthetically lethal knock-outs in regulatory networks [PDF]
Theory in Biosciences, 2012 published version, 10 pages, 6 figures, 2 tables; supplement at http://www.bioinf.uni-leipzig.de/publications/supplements/11 ...
Gunnar Boldhaus +2 more
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Synthetic Lethality through the Lens of Medicinal Chemistry [PDF]
, 2020 Personalized medicine and therapies represent the goal of modern medicine, as drug discovery strives to move away from one-cure-for-all and makes use of the various targets and biomarkers within differing disease areas.
Myers, Samuel H +2 more
core +1 more source
Metabolic synthetic lethality in cancer therapy
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2017 Our understanding of cancer has recently seen a major paradigm shift resulting in it being viewed as a metabolic disorder, and altered cellular metabolism being recognised as a hallmark of cancer. This concept was spurred by the findings that the oncogenic mutations driving tumorigenesis induce a reprogramming of cancer cell metabolism that is required
Zecchini, Vincent, Frezza, Christian
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Defeat mutant KRAS with synthetic lethality [PDF]
Small GTPases, 2016 Ras proteins are considered as the founding members of a large superfamily of small GTPases that control fundamental cellular functions. Mutationally activated RAS genes were discovered in human cancer cells more than 3 decades ago, but intensive efforts on Ras structure, biochemistry, function and signaling continue even now.
Pang, Xiufeng, Liu, Mingyao
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Overcoming selection bias in synthetic lethality prediction
Bioinformatics, 2022 AbstractMotivationSynthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaustive experimental screens is challenging, due to
Colm Seale +2 more
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eLife, 2015 Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over 600 LUAD.
Arun M Unni +4 more
doaj +1 more source
Molecular Oncology, 2011 Poly (ADP‐ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP inhibitors cause an increase in DNA single‐strand breaks (SSBs), which are
Thomas Helleday
doaj +1 more source
eLife, 2015 Intracellular pH (pHi) dynamics is increasingly recognized as an important regulator of a range of normal and pathological cell behaviors. Notably, increased pHi is now acknowledged as a conserved characteristic of cancers and in cell models is confirmed
Bree K Grillo-Hill +3 more
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