Results 1 to 10 of about 8,519 (204)

The Structure and Functions of PRMT5 in Human Diseases

Life, 2021
Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its structure, an increasing number of papers have investigated and delineated the structural and functional role of PRMT5 in diseased conditions.
Tao Lu, Aishat Motolani, Mengyao Sun
exaly   +3 more sources

PRMT5 promotes psoriatic inflammation through mediating dimethylation of p65 in keratinocytes [PDF]

Molecular Medicine
Background Psoriasis is a chronic inflammatory skin disease driven by aberrant keratinocyte activation and immune dysregulation. Protein arginine methyltransferase 5 (PRMT5) was identified as a candidate regulator in psoriatic keratinocytes, yet its ...
Xiaoru Hu, Yuzi Tian, Qingyu Hong, Wanyao Liu, Weina Li, Jia Guo   +5 more
doaj   +2 more sources

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

Cell Reports, 2017
Summary: Breast cancer progression, treatment resistance, and relapse are thought to originate from a small population of tumor cells, breast cancer stem cells (BCSCs).
Abeer M. Shaaban, Maria Pilar Sanchez-Bailon, Olena Barbash   +2 more
exaly   +3 more sources

PRMT5 Regulates ATF4 Transcript Splicing and Oxidative Stress Response

Redox Biology, 2022
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Samir H Barghout, David Dilworth, Genna M. Luciani   +2 more
exaly   +3 more sources

Protein arginine methyltransferase 5 orchestrates the homeostasis and reconstitution of intestinal stem cell niche via balancing urea cycling [PDF]

Cell Communication and Signaling
Background Protein arginine methyltransferase 5 (PRMT5) is highly expressed in many cancers and is a potential therapeutic target. It is also expressed in the small intestine, suggesting a role in intestinal health.
Nan Wang, Xi Wang, Qihang Lian, Yikun Luo, Hefei Tian, Banghui Liu, Yujun Huang, Zhenni Xu, Xudan Lei, Lingxiao Huang, Dengqun Liu   +10 more
doaj   +2 more sources

PRMT5 as a Key Driver of Stemness and Metastatic Potential in Triple-Negative Breast Cancer [PDF]

Biomolecules
Protein arginine methyltransferase 5 (PRMT5) mediates arginine methylation of a wide range of proteins and plays context-dependent oncogenic or tumor-suppressive roles.
Jae Jin Jeong, Mauli Maniar, Shahrzad Ghane, Sakshi Deshpande, Claire Ellis, Ashakumary Lakshmikuttyamma   +5 more
doaj   +2 more sources

The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

Life Science Alliance, 2021
The uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.
Baskar Chakrapani, Mohd Imran K Khan, Rajashekar Varma Kadumuri, Somlee Gupta, Mamta Verma, Sharad Awasthi, Gayathri Govindaraju, Arun Mahesh, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan   +10 more
doaj   +1 more source

PRMT5 Promotes EMT Through Regulating Akt Activity in Human Lung Cancer

Cell Transplantation, 2021
The type II protein arginine methyltransferase 5 (PRMT5) has been engaged in various human cancer development and progression types. Nevertheless, few studies uncover the biological functions of PRMT5 in the epithelial-mesenchymal transition (EMT) of ...
Jianhao Huang, Yonghua Zheng, Xiao Zheng, Bao Qian, Qi Yin, Jingjing Lu, Han Lei   +6 more
doaj   +1 more source

PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression

Frontiers in Pharmacology, 2020
The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy.
Sidong Cai, Rong Liu, Panxia Wang, Jingyan Li, Tingting Xie, Minghui Wang, Yanjun Cao, Zhuoming Li, Peiqing Liu   +8 more
doaj   +1 more source

Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer

Scientific Reports, 2023
Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target with inhibitors being tested in clinical trials. However, it remains unknown how the
Charles Brobbey, Shasha Yin, Liu Liu, Lauren E. Ball, Philip H. Howe, Joe R. Delaney, Wenjian Gan   +6 more
doaj   +1 more source