Results 41 to 50 of about 8,519 (204)
PRMT5 forms a stoichiometric complex with p44 and PRMT5.
, 2012 (A) SDS-PAGE of PRMT5 complexes produced by co-expression in E. coli. (B) Methylation of SmD3 and histone H4 substrates by PRMT5 and PRMT5-containing complexes. Top: autoradiography of the gel. Bottom: Coomassie blue staining of the gel.
Zhongping Gu (144275) +5 more
core +1 more source
Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
Cancer Medicine, 2019 TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted therapy yet exists. Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of arginines on ...
Mathilde Vinet +16 more
doaj +1 more source
The PRMT5-p44 interaction is essential for the PRMT5-promoted p44 cytoplasmic localization.
, 2012 (A) Mutations in p44 abolished PRMT5-driven p44 cytoplasmic translocation. Cells were transfected with pcDNA-GFP-p44(WT) or pcDNA-GFP-p44(MT) alone or together with pcDNA-PRMT5.
Zhongping Gu (144275) +5 more
core +1 more source
The histone‐binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5 [PDF]
, 2008 International audienceProtein arginine methyltransferase 5 (PRMT5) targets nuclear and cytoplasmic proteins. Here, we identified a nuclear protein, called cooperator of PRMT5 (COPR5), involved in the nuclear functions of PRMT5.
Selma El Messaoudi +11 more
core +1 more source
Journal of Biomedical ScienceBackground Various epigenetic modifiers are involved in the regulation of gene expression during pathological cardiac hypertrophy—a critical event in the development of heart failure.
Yasufumi Katanasaka +10 more
doaj +1 more source
Cell Proliferation, EarlyView.Histone modifications at CRISPR–Cas9‐induced DNA double‐strand breaks shape chromatin states and regulate DNA repair pathway choice. Transient epigenetic modulation may provide a promising strategy to enhance CRISPR–Cas9‐mediated gene knock‐in.
Xin Chen +9 more
wiley +1 more source
Lactate and Lactylation: What We Know and What We Expect in Tumour Progression
Cell Proliferation, EarlyView.Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Regulation of RORα Stability through PRMT5-Dependent Symmetric Dimethylation [PDF]
Retinoic acid receptor-related orphan receptor alpha (RORα), a candidate tumor suppressor, is prevalently downregulated or lost in malignant breast cancer cells. However, the mechanisms of how RORα expression is regulated in breast epithelial
Horton, Elise +9 more
core +1 more source