Results 51 to 60 of about 8,519 (204)

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

PRMT5 regulates ovarian follicle development by facilitating Wt1 translation

eLife, 2021
Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine. Here, we found that PRMT5 was expressed at high level in ovarian granulosa cells of growing follicles.
Min Chen, Fangfang Dong, Min Chen, Zhiming Shen, Haowei Wu, Changhuo Cen, Xiuhong Cui, Shilai Bao, Fei Gao   +8 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Ectopic endometrial stromal cells‐derived exosomes accelerate endometriosis progression by delivering PDLIM3 to induce macrophage M2 polarization

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
ecNSCs‐secreted exosomal PDLIM3 stabilizes NAA40 to epigenetically upregulate PRMT1, driving macrophage M2 polarization. Abstract Endometriosis (Ems) is a benign disease characterized by invasion and migration. Abnormally expressed mRNAs regulate its progression.
Chi Chi, Jie Chen, Shuzhen Xiang, Bing Han, Weizeyu Liu, Yi Zhang, Jie Zhang, Min Li   +7 more
wiley   +1 more source

PRMT5 promotes p44 cytoplasmic translocation.

, 2012
(A) Diagrams of the PRMT5 truncations. Cells were transfected with pcDNA-GFP-p44 and pcDNA-PRMT5 or pcDNA-PRMT5 truncations, and the percentages of cells with GFP-p44 in cytoplasm (C) or cytoplasm plus nucleus (C/N) are shown on the right.
Zhongping Gu (144275), Chidan Wan (144282), Tao Liu (10785), Peng Lee (144280), Zhengxin Wang (144284), Yirong Li (144277)   +5 more
core   +1 more source

The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma

, 2021
Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins.
Tanner Wright, Mark T. Bedford, Yalong Wang   +2 more
core   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy

Journal for ImmunoTherapy of Cancer
Background Arginine methyltransferase protein arginine methyltransferase 5 (PRMT5) plays a significant role in immune regulation, particularly within the tumor microenvironment (TME).
Jian Cao, Yongyu Chen, Bingqian Zhou, Shiyu Chen, Zheyi Chen, Yiren Huang, Lisong Shen, Yingxia Zheng   +7 more
doaj   +1 more source

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Cell Reports, 2016
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP).
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks   +16 more
doaj   +1 more source

PRMT5 promotes progression of endometrioid adenocarcinoma via ERα and cell cycle signaling pathways

The Journal of Pathology: Clinical Research, 2021
Protein arginine methyltransferase 5 (PRMT5) has previously been reported to be upregulated in many malignant tumors. This study investigated the significance of PRMT5 in endometrial carcinoma (EC) and explored its function in tumorigenesis ...
Shuyu Mei, Shuang Ge, Jun Wang, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Chaoshuai Xue, Cuijuan Zhang, Tingguo Zhang   +9 more
doaj   +1 more source