Results 31 to 40 of about 8,519 (204)
PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7
Advanced Science, 2021 Protein arginine methyltransferase 5 (PRMT5) is the type II arginine methyltransferase that catalyzes the mono‐ and symmetrical dimethylation of protein substrates at the arginine residues.
Congcong Cai +8 more
doaj +1 more source
PRMT5: An Emerging Target for Pancreatic Adenocarcinoma [PDF]
Cancers, 2021 The overall survival of pancreatic ductal adenocarcinoma (PDAC) remains poor and its incidence is rising. Targetable mutations in PDAC are rare, thus novel therapeutic approaches are needed. Protein arginine methyltransferase 5 (PRMT5) overexpression is associated with worse survival and inhibition of PRMT5 results in decreased cancer growth across ...
Michael K. C. Lee +3 more
openaire +3 more sources
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis [PDF]
, 2015 Epigenetic regulators play critical roles in normal hematopoiesis, and the activity of these enzymes is frequently altered in hematopoietic cancers. The major type II protein arginine methyltransferase PRMT5 catalyzes the formation of symmetric dimethyl ...
Hamard, Pierre-Jacques +10 more
core +1 more source
PLoS ONE, 2021 Non-Hodgkin lymphoma (NHL) is a heterogeneous group of blood cancers arising in lymphoid tissues that commonly effects both humans and dogs. Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the symmetric di-methylation of arginine ...
Shelby L Sloan +18 more
doaj +1 more source
Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors
, 2022 [Image: see text] The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and modulators of its interactions with different regulatory proteins are in high demand because they modulate PRMT5 substrate selectivity. We describe a
Prudent, R. +19 more
core +4 more sources
PRMT5 Promotes Human Lung Cancer Cell Apoptosis via Akt/Gsk3β Signaling Induced by Resveratrol
Cell Transplantation, 2019 Protein arginine methyltransferase 5 (PRMT5) is implicated in various types of human cancer and tumor development, especially in lung cancer. Nevertheless, it is still unclear whether suppression of PRMT5 could promote lung cancer cell apoptosis and ...
Yong Li +4 more
doaj +1 more source
PRMT5 contains three nuclear exclusion signals.
, 2012 (A) Diagrams of the PRMT5 truncations expressed as GFP-fusion proteins. The percentages of cells with GFP-PRMT5 truncations in the cytoplasm (C), nucleus (N), or cytoplasm plus nucleus (C/N) are shown on the right.
Zhongping Gu (144275) +5 more
core +1 more source
PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1
MedComm, 2023 Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human cancers, including in ovarian cancer.
Fei Xie +20 more
doaj +1 more source
The nuclear PRMT5 inhibited the growth of prostate cancer cells.
, 2012 (A) The PRMT5 protein in LNCaP cells expressing PRMT5, PRMT5mt, NLS-PRMT5, or NLS-PRMT5mt was immunostained with the anti-PRMT5 antibody. The samples were observed under a confocal microscope. (B) Western blot of cytoplasmic (C) and nuclear (N) fractions
Zhongping Gu (144275) +5 more
core +1 more source
Scientific Reports, 2021 We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, seen ...
Sara Busacca +17 more
doaj +1 more source