Results 11 to 20 of about 8,519 (204)
Archives of Medical Science, 2020 Introduction Prostate cancer (PCa) is the most common male genitourinary malignancy in the world. The protein arginine methyltransferase 5 (PRMT5) is one of the main members of the type II PRMT family, which was reported to regulate androgen-dependent ...
Hao Shen +5 more
doaj +2 more sources
PRMT5/FGFR3/AKT Signaling Axis Facilitates Lung Cancer Cell Metastasis
Technology in Cancer Research & Treatment, 2023 Objectives: This study aims to investigate the function of the protein arginine methyltransferase 5 (PRMT5) and fibroblast growth factor receptor 3 (FGFR3)/Akt signaling axis in the epithelial-mesenchymal transition (EMT) of human lung cancer.
Yonghua Zheng MD +5 more
doaj +2 more sources
PRMT5 prognostic value in cancer [PDF]
Oncotarget, 2019 Protein arginine methyltransferases (PRMTs) catalyze the methylation of arginine residues on both histones and non-histone proteins. PRMT5, a member of the PRMT family, is overexpressed in a wide variety of cancers and its activity is associated with cell transformation.
Lattouf, Hanine +2 more
openaire +3 more sources
Journal of Clinical InvestigationExpression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al.
Kumar, Rathan, Ranganathan, Parvathi
openaire +3 more sources
CRISPR-Cas9-mediated chicken prmt5 gene knockout and its critical role in interferon regulation
Poultry Science: Protein arginine methyltransferase 5 (PRMT5), a type II arginine methyltransferase, controls arginine dimethylation of a variety of substrates. While many papers have reported the function of mammalian PRMT5, it remains unclear how PRMT5 functions in ...
Qinghua Zeng +10 more
doaj +2 more sources
PRMT5 activates AKT via methylation to promote tumor metastasis [PDF]
, 2022 Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 dysregulation is implicated in multiple oncogenic processes.
Shohet, Jason M. +32 more
core +2 more sources
Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant-state stabilization. [PDF]
Mol OncolArginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
Kwon SH, Lee JM.
europepmc +2 more sources
PRMT5 function and targeting in cancer [PDF]
Cell Stress, 2020 Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways.
Hyungsoo Kim, Ze’ev A. Ronai
openaire +3 more sources
PRMT5/WDR77 complex interacts with ORF1.
, 2023 (A) Co-IP assay of ORF1-Flag, WDR77-HA and PRMT5-HA. HEK293T cells were co-transfected with ORF1-Flag or EGFP-Flag and WDR77-HA, PRMT5-HA constructs. Cell lysates were incubated with Flag antibody. Immunoprecipitated samples were blotted with Flag and HA
Haiteng Deng (138991) +7 more
core +1 more source
PLoS ONE, 2012 Protein arginine methyltransferase 5 (PRMT5) plays multiple roles in a large number of cellular processes, and its subcellular localization is dynamically regulated during mouse development and cellular differentiation.
Zhongping Gu +5 more
doaj +1 more source