Results 21 to 30 of about 8,519 (204)

PRMT5 links lipid metabolism to contractile function of skeletal muscles [PDF]

, 2023
Skeletal muscle plays a key role in systemic energy homeostasis besides its contractile function, but what links these functions is poorly defined. Protein Arginine Methyl Transferase 5 (PRMT5) is a well-known oncoprotein but also expressed in healthy ...
Oprescu, Stephanie N, Snyder, Madigan, Syed, Sabriya A, Kuang, Shihuan, Jia, Zhihao, Chen, Jingjuan, Imbalzano, Anthony N, Yue, Feng, Roseguini, Bruno T, Qiu, Jiamin, Hu, Changdeng, Kim, Kun Ho, Chen, Xiyue   +12 more
core   +1 more source

PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma

Cell Death and Disease, 2021
Protein arginine methyltransferase 5 (PRMT5), a histone methyltransferase responsible for the symmetric dimethylation of histone H4 on Arg 3 (H4R3me2s), is an enzyme that participates in tumor cell progression in a variety of hematological malignancies ...
Tian Xia, Ming Liu, Quan Zhao, Jian Ouyang, Bing Chen, Peipei Xu   +5 more
doaj   +1 more source

PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications

Frontiers in Cell and Developmental Biology, 2021
Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of mono- or symmetric dimethylarginine residues on histones and non-histone substrates and has been demonstrated to play important roles in many biological processes.
Fangfang Dong, Fangfang Dong, Fangfang Dong, Min Chen, Min Chen, Min Chen, Lin Jiang, Zhiming Shen, Zhiming Shen, Zhiming Shen, Longfei Ma, Longfei Ma, Longfei Ma, Chunsheng Han, Chunsheng Han, Chunsheng Han, Xudong Guo, Fei Gao, Fei Gao, Fei Gao   +19 more
doaj   +1 more source

Validation of PRMT5 siRNA.

, 2022
Mouse peritoneal macrophages were transfected with NT or Prmt5 siRNA. Transfected cells were infected with Mtb H37Rv for 24 h and assessed for the expression of PRMT5 by immunoblotting.
Salik Miskat Borbora (9381455), Raju S. Rajmani (11134060), Kithiganahalli Narayanaswamy Balaji (9381464)   +2 more
core   +1 more source

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

BMC Cancer, 2019
Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in ...
Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter   +11 more
doaj   +1 more source

PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity

Frontiers in Immunology, 2021
Multiple Sclerosis (MS) is a debilitating central nervous system disorder associated with inflammatory T cells. Activation and expansion of inflammatory T cells is thought to be behind MS relapses and influence disease severity.
Stephanie A. Amici, Wissam Osman, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +5 more
doaj   +1 more source

The Role of PRMT5 in Immuno-Oncology

Genes, 2023
Immune checkpoint inhibitor (ICI) therapy has caused a paradigm shift in cancer therapeutic strategy. However, this therapy only benefits a subset of patients. The difference in responses to ICIs is believed to be dependent on cancer type and its tumor microenvironment (TME).
Yoshinori Abe, Takumi Sano, Nobuyuki Tanaka   +2 more
openaire   +2 more sources

2467 PRMT5 is a master epigenetic regulator to promote repair of radiation-induced DNA damage

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: We recently reported that PRMT5 epigenetically activates androgen receptor (AR) in prostate cancer cells. Because targeting AR signaling through androgen deprivation therapy is clinically used as a radiosensitization approach to
Jake L. Owens
doaj   +1 more source

PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis

Journal for ImmunoTherapy of Cancer, 2023
Background As an emerging treatment strategy for triple-negative breast cancer (TNBC), immunotherapy acts in part by inducing ferroptosis. Recent studies have shown that protein arginine methyltransferase 5 (PRMT5) has distinct roles in immunotherapy ...
Jian Zhang, Bo Zhang, Ting Wang, Cheng Ji, Rui Ling, Zhe Wang, Qing Yao, Jie Duan, Jing Kong, Yaping Wang, Ge Zhao, Ruolei Li, Niuniu Hou, Juliang Zhang, Pengyu Fan, Liuyin Liu   +15 more
doaj   +1 more source

Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production

Viruses, 2020
Current therapies for human immunodeficiency virus type 1 (HIV-1) do not completely eliminate viral reservoirs in cells, such as macrophages. The HIV-1 accessory protein viral protein R (Vpr) promotes virus production in macrophages, and the maintenance ...
Hironobu Murakami, Takehiro Suzuki, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Manabu Taura, Eriko Kudo, Seiji Okada, Masami Takei, Kazumichi Kuroda, Tatsuo Yamamoto, Kyoji Hagiwara, Naoshi Dohmae, Yoko Aida   +12 more
doaj   +1 more source