Results 71 to 80 of about 1,044,115 (187)

Therapeutic Role of Synthetic Lethality in ARID1A-Deficient Malignancies [PDF]

Journal of Immunotherapy and Precision Oncology
AT-rich interaction domain 1A (ARID1A), a mammalian switch/sucrose nonfermenting complex subunit, modulates several cellular processes by regulating chromatin accessibility.
Kyaw Z. Hein, Bettzy Stephen, Siqing Fu
doaj   +1 more source

Synthetic lethality: general principles, utility and detection using genetic screens in human cells. [PDF]

, 2010
Synthetic lethality occurs when the simultaneous perturbation of two genes results in cellular or organismal death. Synthetic lethality also occurs between genes and small molecules, and can be used to elucidate the mechanism of action of drugs.
Sebastian M.B. Nijman, Nijman, Sebastian, Nijman, SM, Nijman, Sebastian M.B.   +3 more
core   +1 more source

Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28

G3: Genes, Genomes, Genetics, 2017
Cdk1 (Cdc28 in yeast) is a cyclin-dependent kinase (CDK) essential for cell cycle progression and cell division in normal cells. However, CDK activity also underpins proliferation of tumor cells, making it a relevant study subject. While numerous targets
Christine Zimmermann, Ignacio Garcia, Manja Omerzu, Pierre Chymkowitch, Beibei Zhang, Jorrit M. Enserink   +5 more
doaj   +1 more source

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

Cell Reports, 2018
Summary: PARP inhibitors (PARPis) have been used to induce synthetic lethality in BRCA-deficient tumors in clinical trials with limited success. We hypothesized that RAD52-mediated DNA repair remains active in PARPi-treated BRCA-deficient tumor cells and
Katherine Sullivan-Reed, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, Samantha Langer, Micheal Siciliano, Margaret Nieborowska-Skorska, Kritika Hanamshet, Elizaveta A. Belyaeva, Andrea J. Bernhardy, Jaewong Lee, Morgan Moore, Huaqing Zhao, Peter Valent, Ksenia Matlawska-Wasowska, Markus Müschen, Smita Bhatia, Ravi Bhatia, Neil Johnson, Mariusz A. Wasik, Alexander V. Mazin, Tomasz Skorski   +20 more
doaj   +1 more source

Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies [PDF]

, 2014
Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not.
Wu, Min, Li, Xue-juan, Zheng, Jie, Mishra, Shital K., Zhang, Fan   +4 more
core   +1 more source

Genome‐scale gene/reaction essentiality and synthetic lethality analysis

Molecular Systems Biology, 2009
Synthetic lethals are to pairs of non‐essential genes whose simultaneous deletion prohibits growth. One can extend the concept of synthetic lethality by considering gene groups of increasing size where only the simultaneous elimination of all genes is ...
Patrick F Suthers, Alireza Zomorrodi, Costas D Maranas   +2 more
doaj   +1 more source

Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy

Neoplasia: An International Journal for Oncology Research
The ATR-CHK1 pathway plays a fundamental role in the DNA damage response and is therefore an attractive target in cancer therapy. The antitumorous effect of ATR inhibitors is at least partly caused by synthetic lethality between ATR and various DNA ...
Hanna Elisabeth Schneider, Lisa-Maria Schmitt, Albert Job, Brigitte Lankat-Buttgereit, Thomas Gress, Malte Buchholz, Eike Gallmeier   +6 more
doaj   +1 more source

TARGETING EPHB6 SYNTHETIC LETHALITY IN BREAST CANCER [PDF]

, 2019
Traditionally, cancer treatments focus on proteins impacted by either an increase in expression or a gain-of-function mutation. Loss-of-function mutations or especially down-regulation usually cannot be targeted directly through stabilization or ...
Greidanus, Paul 1995-
core  

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality [PDF]

, 2014
Synthetic lethality occurs when the inhibition of two genes is lethal while the inhibition of each single gene is not. It can be harnessed to selectively treat cancer by identifying inactive genes in a given cancer and targeting their synthetic lethal ...
McGarry, Lynn, James, Daniel, Jerby-Arnon, Livnat, Geiger, Tamar, Pfetzer, Nadja, Waldman, Yedael Y., Gottlieb, Eyal, Shanks, Emma, Seashore-Ludlow, Brinton, Clemons, Paul A., Weinstock, Adam, Ruppin, Eytan   +11 more
core   +1 more source

Genetic interaction motif finding by expectation maximization – a novel statistical model for inferring gene modules from synthetic lethality

BMC Bioinformatics, 2005
Background Synthetic lethality experiments identify pairs of genes with complementary function. More direct functional associations (for example greater probability of membership in a single protein complex) may be inferred between genes that share ...
Ye Ping, Qi Yan, Bader Joel S
doaj   +1 more source