Results 91 to 100 of about 1,044,115 (187)

Computational methods for predicting synthetic lethality in cancer

Cancer, the second leading cause of death worldwide, is primarily driven by genetic mutations. While targeted therapies offer the advantage of minimizing damage to normal cells by selectively targeting cancerous ones, they are limited by the challenge of
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A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer

Nature Communications
The deregulated activation of the phosphoinositide 3-kinase (PI3K) pathway is a hallmark of aggressive tumors with metabolic plasticity, eliciting their adaptation to the microenvironment and resistance to chemotherapy. A significant gap lies between the
Guillaume P. Andrieu, Mathieu Simonin, Aurélie Cabannes-Hamy, Etienne Lengliné, Ambroise Marçais, Alexandre Théron, Grégoire Huré, Jérome Doss, Ivan Nemazanyy, Marie Émilie Dourthe, Nicolas Boissel, Hervé Dombret, Philippe Rousselot, Olivier Hermine, Vahid Asnafi   +14 more
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Synthetic lethality in lung cancer and translation to clinical therapies

, 2018
Lung cancer is a heterogeneous disease consisting of multiple histological subtypes each driven by unique genetic alterations. Despite the development of targeted therapies that inhibit the oncogenic mutations driving a subset of lung cancer cases, there
de Silva, Tanya, Leung, Ada W. Y., Lockwood, William W., Bally, Marcel B., 1956-   +3 more
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SynLethDB: synthetic lethality database towards discovery of selective and sensitive anticancer drug targets

, 2017
This dataset is used in the SynLethDB which is the first comprehensive database that harbours a large set of synthetic lethality (SL) gene pairs collected from a variety of sources including biochemical assays, other related databases, computational ...
Zheng, Jie
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Synthetic lethality guiding selection of drug combinations in ovarian cancer

, 2019
BackgroundSynthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but simultaneous loss of both gene functions results in lethality. Targeting synthetic lethal
Michael Krainer (42689), Michael Krainer, Michael Schwarz, Paul Mayer, Paul Perco, Maximilian Marhold (3764131), Heinzel, Andreas, Maximilian Marhold, Schwarz, Michael, Andreas Heinzel, Tomasich, Erwin, Michael Schwarz (209306), Arno Lukas, Krainer, Michael, Andreas Heinzel (610394), Paul Perco (32894), Marhold, Maximilian, Perco, Paul, Paul Mayer (611308), Arno Lukas (32895), Erwin Tomasich, Lukas, Arno, Erwin Tomasich (3764128), Mayer, Paul   +23 more
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PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer

, 2011
Evasion of apoptosis contributes to both tumourigenesis and drug resistance in non-small cell lung carcinoma (NSCLC). The pro-apoptotic BCL-2 family proteins BAX and BAK are critical regulators of mitochondrial apoptosis.
Blayney, Jaine K, Kerr, K., Lamers, Elisabeth, Kerr, Keith, Harkin, D Paul, Ian Paul, Kienan I Savage, Derek J Richard, O'Byrne, K.J., Savage, Kienan I, Hamilton, Peter, Keith Kerr, Dean A Fennell, Kenneth J O'Byrne, D Paul Harkin, James, Jacqueline A, Kathy Gately, Gately, K., O'Byrne, Kenneth J, Harkin, Paul, Quinn, Jennifer E, Peter W Hamilton, Paul, I., Hamilton, Peter W, Gately, Kathy, Kenneth Arthur, James, Jacqueline, Jaine K Blayney, Savage, Kienan, Quinn, J.E., Paul, Ian, Elisabeth Lamers, Lamers-Schmidt, Elisabeth, Richard, D.J., Fennell, Dean A, Jennifer E Quinn, Blayney, Jaine, Jacqueline A James, Sheaff, M., Sheaff, Michael, Richard, Derek J., Arthur, Kenneth, Fennell, Dean, Michael Sheaff   +43 more
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150 Genome Informatics 16(1): 150–158 (2005) Comprehensive Analysis and Prediction of Synthetic Lethality Using Subcellular Locations

, 2008
The lethality of a gene is a fundamental and representative measure for understanding the function of a gene and its associated bio-systems. Recently, many research groups have started focusing on the concept of synthetic lethality.
Hiroshi Mamitsuka, Takuji Yamada, Shuichi Kawashima, Susumu Goto, Minoru Kanehisa   +4 more
core  

Targeting ALC1 for synthetic lethality in cancer [PDF]

Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown great potential in cancer treatment by selectively targeting DNA repair pathways and inducing synthetic lethality, leading to improved patient outcomes.
Sahiri, Katharina Arien
core  

DNA repair in cancer: emerging targets for personalized therapy

Cancer Management and Research, 2014
Rachel Abbotts, Nicola Thompson, Srinivasan Madhusudan University of Nottingham, Academic Unit of Oncology, Division of Oncology, School of Medicine, Nottingham University Hospitals, City Hospital Campus, Nottingham, UK Abstract: Genomic ...
Abbotts R, Thompson N, Madhusudan S
doaj  

Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells. [PDF]

Cancer Res
Kim EJ, Jin DX, Chibly AM, Dorighi K, Sivakumar S, Kamm J, Juszkiewicz S, Cabrera K, Reja R, Wang Y, Nakagawa R, Shi M, Liang Y, Dey A, Sokol ES, Gendreau S, He M.   +16 more
europepmc   +1 more source