Results 91 to 100 of about 1,770,471 (326)
Graph Contextualized Attention Network for Predicting Synthetic Lethality in Human Cancers
bioRxiv, 2021 Motivation Synthetic Lethality (SL) plays an increasingly critical role in the targeted anticancer therapeutics. In addition, identifying SL interactions can create opportunities to selectively kill cancer cells without harming normal cells.
Yahui Long +6 more
semanticscholar +1 more source
Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy
Frontiers in Oncology, 2023 DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing.
Ananna Bhadra Arna +7 more
doaj +1 more source
Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution [PDF]
, 2011 Here, I merge the principles of synthetic biology^1,2^ and regulatory evolution^3-11^ to create a new species^12-15^ with a minimal set of known elements.
Eduardo Moreno
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Genetic mapping and predictive modeling of paralog synthetic lethality
Cell ReportsSummary: Paralogs are abundant in the human genome and thought to be a primary source of synthetic lethality, yet the vast paralogome remains largely uncharacterized. A digenic screen of 36,648 paralogous pairs in the human genome revealed that synthetic
Michael J. Flister +7 more
doaj +1 more source
Cell line name recognition in support of the identification of synthetic lethality in cancer from text [PDF]
, 2015 Motivation: The recognition and normalization of cell line names in text is an important task in biomedical text mining research, facilitating for instance the identification of synthetically lethal genes from the literature.
Ginter, Filip +5 more
core +2 more sources
THE PROBLEM OF SYNTHETIC LETHALS IN DROSOPHILA MELANOGASTER [PDF]
Genetics, 1956 Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Drugs in Context, 2018 Over the last decade, new therapeutics in the form of anti-angiogenic treatment, synthetic lethality, and checkpoint inhibition have offered new options for the treatment of ovarian cancer.
Marisa C Liu, Krishnansu S Tewari
doaj +1 more source
Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]
, 2014 RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Abd Wahab +68 more
core +2 more sources