Results 111 to 120 of about 1,770,471 (326)

Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality

Molecular Cancer, 2021
Synthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a significant effect on cell viability. This concept can be exploited to specifically target tumor cells.
Salvatore Benfatto, Özdemirhan Serçin, F. Dejure, A. Abdollahi, F. Zenke, Balca R. Mardin   +5 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

eLife, 2015
Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over 600 LUAD.
Arun M Unni, William W Lockwood, Kreshnik Zejnullahu, Shih-Queen Lee-Lin, Harold Varmus   +4 more
doaj   +1 more source

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil.

PLoS ONE, 2021
A synthetic lethal effect arises when a cancer-associated change introduces a unique vulnerability to cancer cells that makes them unusually susceptible to a drug's inhibitory activity.
Jing Zhang, Shenqiu Zhang, Qiong Shi, Thaddeus D Allen, Fengming You, Dun Yang   +5 more
doaj   +1 more source

PARP inhibition: a promising therapeutic target in ovarian cancer [PDF]

, 2015
Ovarian cancer is burdened by the highest mortality rate among gynecological cancers. Gold standard is represented by the association of platinum-taxane -based chemotherapy and radical surgery.
Abdul Halim, T, BENEDETTI PANICI, PIERLUIGI, CASORELLI, ASSUNTA, DI DONATO, VIOLANTE, DOMENICI, LAVINIA, GASPARRI, MARIALUISA, IMPERIALE, LUDOVICA, MARCHETTI, CLAUDIA, MONTI, Marco, MUSELLA, ANGELA, MUZII, LUDOVICO, PALAIA, INNOCENZA, PECORINI, Francesco, RUSCITO, ILARY, SALERNO, LAURA   +14 more
core   +1 more source

CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer

Cancers, 2021
Simple Summary The synthetic lethality (SL) clinical success of PARP inhibitors in homologous recombinant deficient tumors has established a new concept for cancer treatment.
Laia Castells-Roca, Eudald Tejero, B. Rodríguez-Santiago, J. Surrallés   +3 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

eLife, 2015
Intracellular pH (pHi) dynamics is increasingly recognized as an important regulator of a range of normal and pathological cell behaviors. Notably, increased pHi is now acknowledged as a conserved characteristic of cancers and in cell models is confirmed
Bree K Grillo-Hill, Changhoon Choi, Maite Jimenez-Vidal, Diane L Barber   +3 more
doaj   +1 more source

Combatting melioidosis with chemical synthetic lethality. [PDF]

Proc Natl Acad Sci U S A
Burkholderia thailandensis has emerged as a nonpathogenic surrogate for Burkholderia pseudomallei , the causative agent of melioidosis, and an important Gram-negative model bacterium for studying the biosynthesis and regulation of secondary metabolism.
Zhang Y, McWhorter KL, Rosen PC, Klaus JR, Gallant É, Amaya Lopez CY, Jhunjhunwala R, Chandler JR, Davis KM, Seyedsayamdost MR.   +9 more
europepmc   +3 more sources

ETAA1 ensures proper chromosome segregation: A matter of S phase or mitosis? [PDF]

, 2019
ETAA1 activates the master checkpoint kinase ATR. Bass and Cortez (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201810058) recently reported an intra-mitotic function of ETAA1 that safeguards chromosome stability.
Achuthankutty, Bass, Bass, Feng, Haahr, Kabeche, Lee, Marina Alejandra González Besteiro, Miosge, Saldivar, Saldivar, Vanesa Gottifredi, Zhou   +12 more
core   +1 more source