Results 131 to 140 of about 1,044,115 (187)

Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors. [PDF]

Sci Adv
Feng M, Liu H, Zheng L, Liu Y, Zhuang H, Xu H, Zhang T, Wu Z, Qian X, Li H, Xiao T, Pan Y, Shu S, Zhang N.   +13 more
europepmc   +1 more source

Chromosome 3p Deletion Leads to Extensive Genomic Alterations in Diverse Cancers and Confers Synthetic Lethality in Uveal Melanoma. [PDF]

Cancers (Basel)
Cutler MC, Howland PB, Hejna M, Song JS.
europepmc   +1 more source

Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer. [PDF]

Cancer Sci
Tani M, Hatano K, Ishizuya Y, Oka T, Kanaki T, Inoguchi S, Yoshimura A, Horibe Y, Liu Y, Nesrine S, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Yamaguchi T, Obika S, Yusa K, Nonomura N, Nimura K.   +22 more
europepmc   +1 more source

Epigenetic synthetic lethality as a cancer therapeutic strategy: synergy of experimental and computational approaches. [PDF]

Epigenomics
Farina-Morillas M, Ollé-Monràs L, Maas SC, de Rojas-P I, Segura MF, Seoane JA.   +5 more
europepmc   +1 more source

Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma. [PDF]

Leukemia
Gao J, Zhao X, Yin Q, Hu A, Qiu K, Blackburn L, Lei L, Xiong R, Bi C, Craig JW, Portell CA, Davila ML, Williams ME, Tao J.   +13 more
europepmc   +1 more source

Repurposing clinically safe drugs for DNA repair pathway choice in CRISPR genome editing and synthetic lethality. [PDF]

Nat Commun
Macak D, Kanis P, Riesenberg S.
europepmc   +1 more source

Replication protein A protects lagging strand gaps, restricting PARP inhibitor-induced synthetic lethality in BRCA1-deficient tumors. [PDF]

Nucleic Acids Res
VanderVere-Carozza PS, Jordan MR, Garrett JE, Pollok KE, Pawelczak KS, Turchi JJ.   +5 more
europepmc   +1 more source

Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems. [PDF]

Genes Dev
Nelson CB, Wells JK, Kesarwani E, Sobinoff AP, Fernando M, Gao J, MacKenzie KL, Poulos RC, Nawaz U, Wang X, Ford HL, Pickett HA.   +11 more
europepmc   +1 more source

Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns. [PDF]

PLoS Comput Biol
Yavuz BR, Sahin U, Jang H, Nussinov R, Tuncbag N.   +4 more
europepmc   +1 more source

Establishment of novel cholangiocarcinoma cell lines with ARID1A deficiency and preclinical validation of synthetic lethality therapies. [PDF]

Sci Rep
Prasopporn S, Sittithumcharee G, Chanthercrob J, Limsrichamrern S, Hirankitti A, More-Krong P, Sathirareuangchai S, Chaiboonchoe A, Sampattavanich S, Okada S, Jirawatnotai S.   +10 more
europepmc   +1 more source