Results 81 to 90 of about 1,044,115 (187)

Development of Synthetic Lethality Anticancer Therapeutics [PDF]

Journal of Medicinal Chemistry, 2014
The concept of synthetic lethality (the creation of a lethal phenotype from the combined effects of mutations in two or more genes) has recently been exploited in various efforts to develop new genotype-selective anticancer therapeutics. These efforts include screening for novel anticancer agents, identifying novel therapeutic targets, characterizing ...
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Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Cell Reports, 2018
Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4).
Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall   +9 more
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Synthetic lethality-based targets for discovery of new cancer therapeutics.

, 2011
Synthetic lethality is based on the incompatibility of cell survival with the loss of function of two or more genes, not with loss of function of a single gene. If targets of synthetic lethality are deregulated or mutated in cancer cells, the strategy of
Weidle, U.H., Eick, D., Maisel, D.
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Combatting melioidosis with chemical synthetic lethality

Proceedings of the National Academy of Sciences
Burkholderia thailandensis has emerged as a nonpathogenic surrogate for Burkholderia pseudomallei , the causative agent of melioidosis, and an important Gram-negative model bacterium for studying the biosynthesis and regulation of secondary metabolism. We recently reported
Yifan Zhang, Kirklin L. McWhorter, Paul C. Rosen, Jennifer R. Klaus, Étienne Gallant, Cindy Y. Amaya Lopez, Riddhi Jhunjhunwala, Josephine R. Chandler, Katherine M. Davis, Mohammad R. Seyedsayamdost   +9 more
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Perspectives on cancer therapy—synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges

Cell Death Discovery
In recent years, synthetic lethality has become an important theme in the field of targeted cancer therapy. Synthetic lethality refers to simultaneous defects in two or more genes leading to cell death, whereas defects in any single gene do not lead to ...
Shixuan Peng, Mengle Long, Qisheng Chen, Zhijian Yin, Chang Zeng, Wanyong Zhang, Qingyang Wen, Xinwen Zhang, Weiqi Ke, Yongjun Wu   +9 more
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New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives [PDF]

In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer therapies. The discovery of a growing number of synthetic lethal targets has led to a significant expansion in the use of synthetic lethality, far beyond poly ...
Bagnolini, Greta, Ferrandi, Giovanni, Ciamarone, Andrea, Rinaldi, Francesco, Roberti, Marinella, Previtali, Viola, Myers, Samuel Harry, Cavalli, Andrea   +7 more
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RET Inhibitor SPP86 Is a Potential Candidate for the Clinical Treatment of Cutaneous Melanoma [Letter]

Drug Design, Development and Therapy
Yingjian Tan, Rui Li Department of Dermatology, Fuzhou First General Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Rui Li, Email 15773250213@163 ...
Tan Y, Li R
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Gene essentiality and synthetic lethality in haploid human cells

, 2015
International audienceAlthough the genes essential for life have been identified in less complex model organisms, their elucidation in human cells has been hindered by technical barriers.
Majek, P., Superti-Furga, G., Nieuwenhuis, J., Carette, J., Staring, J., Blomen, V., Bennett, K., Jae, L., Olk, N., van Diemen, F., Sacco, R., Colinge, J., Janssen, H., Bigenzahn, J., Stukalov, A., Marceau, C., Brummelkamp, T.   +16 more
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Lethal weapon: targeting cancer by synthetic lethality

The Biochemist
The Biochemical Society identifies and celebrates outstanding science communication talent in molecular biosciences with its annual Science Communication Prize. Libbie Elliott won the second prize in the Higher Education category. Libbie’s entry is titled ‘Lethal weapon: targeting cancer by synthetic lethality’.
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Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli

, 2014
Recent genomic analyses on the cellular metabolic network show that reaction flux across enzymes are diverse and exhibit power-law behavior in its distribution.
Goh, KI, Ghim, Cheol-Min, Kahng, B
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