Results 81 to 90 of about 1,770,471 (326)

Nitric Oxide: Genomic Instability And Synthetic Lethality

Redox Biology, 2015
Regardless of etiology, inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide and reactive nitrogen species (NO/RNS) in epithelial and inflammatory cells at the site of ...
Vasily A. Yakovlev
doaj   +1 more source

New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives

Journal of Medicinal Chemistry
In recent years, synthetic lethality has been recognized as a solid paradigm for anticancer therapies. The discovery of a growing number of synthetic lethal targets has led to a significant expansion in the use of synthetic lethality, far beyond poly(ADP-
Viola Previtali, Greta Bagnolini, Andrea Ciamarone, Giovanni Ferrandi, Francesco Rinaldi, Samuel H. Myers, M. Roberti, Andrea Cavalli   +7 more
semanticscholar   +1 more source

PARP inhibitors: Synthetic lethality in the clinic [PDF]

Science, 2017
PARP inhibitors (PARPi), a cancer therapy targeting poly(ADP-ribose) polymerase, are the first clinically approved drugs designed to exploit synthetic lethality, a genetic concept proposed nearly a century ago. Tumors arising in patients who carry germline mutations in either BRCA1 or
Christopher J. Lord, Alan Ashworth
openaire   +4 more sources

Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

Disease Models & Mechanisms, 2012
The post-genomic era is marked by a pressing need to functionally characterize genes through understanding gene-gene interactions, as well as interactions between biological pathways.
Vinita A. Hajeri, James F. Amatruda
doaj   +1 more source

High-throughput, quantitative analyses of genetic interactions in E. coli. [PDF]

, 2008
Large-scale genetic interaction studies provide the basis for defining gene function and pathway architecture. Recent advances in the ability to generate double mutants en masse in Saccharomyces cerevisiae have dramatically accelerated the acquisition of
A Roguev, AB Byrne, AE Rizzitello, AH Tong, AH Tong, Athanasios Typas, Barry L Wanner, Bentley Lim, BJ Bachmann, BJ Breitkreutz, BR Bochner, C Boone, C Onufryk, Carol A Gross, CS Chen, Deborah A Siegele, E Cascales, E Cascales, ES Charlson, G Butland, Hannes Braberg, Hirotada Mori, HJ Nielsen, HJ Nielsen, HS Girgis, J Pogliano, J Qu, JC Bardwell, JG Sklar, Jonathan S Weissman, K Ara, KB Low, LI Leichert, LM Parsons, M Ito, M Schuldiner, MA Gerding, Michael Shales, Natsuko Yamamoto, Nevan J Krogan, P Mazurkiewicz, PE Rouviere, PN Danese, Rikiya Takeuchi, Robert J Nichols, Sean R Collins, SR Collins, SR Collins, T Baba, T Inoue, V Francois, WP Hoekstra, X Pan   +52 more
core   +1 more source

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy

MedComm – Oncology
Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles of SL have
Meiyi Ge, Jian Luo, Yi Wu, Guobo Shen, Xi Kuang   +4 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Bogoch Replikins Pandemic Prevention: Increase of Strain-Specific Influenza Genomic Replikin Counts, Having Predicted Outbreaks and their Location Seven Times Consecutively, Up to Two Years in Advance, Provides Time for Prevention of Pandemics [PDF]

, 2012
Earlier studies have shown that the increased concentration of a new class of virus genomic peptides, Replikins, precedes and predicts virus outbreaks. We now find that the area in the genome of the highest concentration of Replikins, and the country in ...
Elenore S. Bogoch, Samuel Bogoch
core   +2 more sources

Cryo-shocked tumor cells deliver CRISPR-Cas9 for lung cancer regression by synthetic lethality

Science Advances
Although CRISPR-mediated genome editing holds promise for cancer therapy, inadequate tumor targeting and potential off-target side effects hamper its outcomes.
Feng Liu, Minhang Xin, Huiheng Feng, Wentao Zhang, Ziyan Liao, Tao Sheng, Ping Wen, Qing Wu, Tingxizi Liang, Jiaqi Shi, Ruyi Zhou, Kaixin He, Zhen Gu, Hongjun Li   +13 more
semanticscholar   +1 more source