Results 61 to 70 of about 1,770,471 (326)

RNase HI Is Essential for Survival of Mycobacterium smegmatis [PDF]

, 2015
RNases H are involved in the removal of RNA from RNA/DNA hybrids. Type I RNases H are thought to recognize and cleave the RNA/DNA duplex when at least four ribonucleotides are present.
Brzostek, Anna M., Dziadek, Bozena, Dziadek, Jaroslaw, Korycka- Machala, Malgorzata, Madiraju, Murty, Minias, Alina E., Minias, Piotr, Rajagopalan, Malini   +7 more
core   +8 more sources

Defective DNA repair mechanisms in prostate cancer: impact of olaparib [PDF]

, 2017
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects.
De Felice, Francesca, Marampon, Francesco, Marchetti, Claudia, Musella, Angela, Tombolini, Vincenzo   +4 more
core   +2 more sources

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Molecular Cancer Therapeutics, 2022
CRISPR Cas9-based screening is a powerful approach for identifying and characterizing novel drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitinating enzyme USP1 in cancers with underlying DNA damage vulnerabilities ...
A. Simoneau, Justin L. Engel, Madhavi Bandi, Katherine Lazarides, Shangtao Liu, Samuel R. Meier, Ashley H Choi, Hongxiang Zhang, B. Shen, L. Martires, D. Gotur, Truc V Pham, Fang Li, L. Gu, Shanzhong Gong, Minjie Zhang, E. Wilker, Xuewen Pan, D. Whittington, Scott Throner, John P Maxwell, Ying-ping Chen, Yi Yu, A. Huang, Jannik N. Andersen, Tianshu Feng   +25 more
semanticscholar   +1 more source

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Acta Pharmaceutica Sinica B, 2020
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic
Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, Yifan Liu, Changjie Wu, Lakhansing Pardeshi, Kaeling Tan, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim   +10 more
doaj   +1 more source

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

mBio, 2023
Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb).
Yuanyuan Xu, Sabine Ehrt, Dirk Schnappinger, Tiago Beites   +3 more
doaj   +1 more source

A multi-species functional embedding integrating sequence and network structure [PDF]

, 2017
A key challenge to transferring knowledge between species is that different species have fundamentally different genetic architectures. Initial computational approaches to transfer knowledge across species have relied on measures of heredity such as ...
Cannistra, Anthony, Crovella, Mark, Fan, Jason, Fried, Inbar, Hescott, Benjamin, Leiserson, Mark D. M., Lim, Tim, Schaffner, Thomas   +7 more
core   +1 more source

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. [PDF]

, 2017
Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the ...
A Magi, AM Spence, Anthony Letai, AV Follis, AV Vaseva, BA Tannous, BJ Altman, Brian Higgins, C Tovar, CW Brennan, D Jiang, D Nathanson, DA Nathanson, DA Reardon, David A Nathanson, DR Green, E Cerami, E Strom, E Tasdemir, EH Cheng, EQ Lee, G Lessene, H Dai, H Takanaga, Harley I Kornblum, I Babic, I Vivanco, J Deng, J Gao, J Lee, J Lehár, J Montero, J Pomerantz, Jason T Lee, JC Liu, JE Chipuk, JE Chipuk, JE Chipuk, JIJ Leu, Jonathan E Tsang, JP Kruse, K Masui, L Qu, Laura Gosa, Lisa Ta, M Mihara, M-K Han, MG Vander Heiden, Mitra Dehghan Harati, MJ Lee, Nicholas A Bayley, OD Maddocks, P Nagesh Rao, Paul S Mischel, Peter M Clark, PM Clark, PY Wen, Q Ding, R Haq, RGW Verhaak, RJ DeBerardinis, Steven J Bensinger, TF Cloughesy, Timothy F Cloughesy, Veerle W Daniels, W Blake Gilmore, W Wei, WH Yang, William H Yong, Wilson X Mai, Y Zhang, Y Zhao   +71 more
core   +1 more source

Computational methods, databases and tools for synthetic lethality prediction

Briefings Bioinform., 2022
Synthetic lethality (SL) occurs between two genes when the inactivation of either gene alone has no effect on cell survival but the inactivation of both genes results in cell death.
Jing Wang, Qinglong Zhang, Ju-cai Han, Yanpeng Zhao, Caiyun Zhao, Bowei Yan, Chong Dai, Lianlian Wu, Yuqi Wen, Yixin Zhang, D. Leng, Zhongming Wang, Xiaoxi Yang, Song He, Xiaochen Bo   +14 more
semanticscholar   +1 more source

RAD52: Paradigm of Synthetic Lethality and New Developments

Frontiers in Genetics, 2021
DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA damage that cause genomic instability that lead to cancer development.
Matthew J. Rossi, Sarah F. DiDomenico, Mikir Patel, Alexander V. Mazin   +3 more
doaj   +1 more source

Inferring the function of genes from synthetic lethal mutations [PDF]

, 2008
Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways with a shared function.
Bryant, CH, Ray, O
core   +1 more source