Results 61 to 70 of about 1,044,115 (187)
DNA Double Strand Break Repair - Related Synthetic Lethality
, 2019 Cancer is a heterogeneous disease with a high degree of diversity between and within tumors. Our limited knowledge of their biology results in ineffective treatment.
Tomasz Skorski +2 more
core +1 more source
Synthetic lethality to overcome cancer drug resistance
, 2012 A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be ...
Paradiso A +7 more
core +2 more sources
Translational Oncology: TNG908 is a clinical stage PRMT5 inhibitor with an MTA-cooperative binding mechanism designed to leverage the synthetic lethal interaction between PRMT5 inhibition and MTAP deletion.
Kimberly J. Briggs +14 more
doaj +1 more source
Epigenetic based synthetic lethal strategies in human cancers
Biomarker Research, 2020 Over the past decades, it is recognized that loss of DNA damage repair (DDR) pathways is an early and frequent event in tumorigenesis, occurring in 40-50% of many cancer types.
Aiai Gao, Mingzhou Guo
doaj +1 more source
Synthetically lethal nanoparticles for treatment of endometrial cancer [PDF]
Nature Nanotechnology, 2017 Uterine serous carcinoma, one of the most aggressive types of endometrial cancer, is characterized by poor outcomes and mutations in the tumour suppressor p53. Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline treatment for endometrial cancer, in tumours with mutant p53 and enhance the therapeutic efficacy using ...
Ebeid, Kareem +11 more
openaire +2 more sources
shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts [PDF]
, 2005 Previously, we demonstrated the establishment of synthetic lethality screening in cultured somatic human cells, or mouse embryo fibroblasts (MEFs), for chemicals or mutant genes synergistically lethal with a mutated gene of interest.
Agami, Reuven +5 more
core +1 more source
Defective cell cycle checkpoints as targets for anti-cancer therapies
Frontiers in Pharmacology, 2012 Conventional chemotherapeutics target the proliferating fraction of cells, which will include the tumour cells, but are also toxic to actively proliferating normal tissues.
Brian eGabrielli +2 more
doaj +1 more source
Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection. [PDF]
PLoS ONE, 2016 It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libraries:
Katherine Sullivan +7 more
doaj +1 more source
An in-silico approach to predict and exploit synthetic lethality in cancer metabolism
Nature Communications, 2017 Exploiting synthetic lethality is a promising approach for cancer therapy. Here, the authors present an approach to identifying such interactions by finding genetic minimal cut sets (gMCSs) that block cancer proliferation, and apply it to study the ...
Iñigo Apaolaza +7 more
doaj +1 more source
A Method for Fast, High-Precision Characterization of Synthetic Biology Devices [PDF]
, 2012 Engineering biological systems with predictable behavior is a foundational goal of synthetic biology. To accomplish this, it is important to accurately characterize the behavior of biological devices.
Weiss, Ron +4 more
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