Results 81 to 90 of about 5,026 (303)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

On the Flux Linkage between Pancake Coils in Resonance-Type Wireless Power Transfer Systems

open access: yesInternational Journal of Antennas and Propagation, 2020
This work presents a series representation for the mutual inductance of two coaxial pancake coils which remains accurate in non-quasi-static regime under the hypothesis that the current in the source coil is uniformly distributed.
Mauro Parise   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Comparative Evaluation of the Air Core Magnetic Design for MHz+ Switching Frequency

open access: yesApplied Sciences
Power electronics with a possible novel distributed system pose fresh challenges and require continuous improvement. One approach is to increase the switching frequency, thereby reducing size and weight.
Oleksandr Matiushkin   +5 more
doaj   +1 more source

Theoretical Analysis of Planar Spiral Coils between Two Multilayer Media for Electric Vehicle Wireless Charging

open access: yesEnergies, 2018
Square and circular coils are two typical topologies for coupling coils and are applied to wireless charging. However, most of the research on coupling coils is based on the finite element model (FEM), which is a time-consuming process for 3-D structure ...
Zhichao Luo, Xuezhe Wei
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Macromodeling of Mutual Inductance for Displaced Coils Based on Laplace's Equation

open access: yes, 2021
Magnetic coupling is applied in a vast of different applications like sensors or medical imaging. Especially for inductive position sensors, magnetic coupling is a main aspect.
Weber, Harry   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

THYRISTOR RESONANT DEVICES WITH MUTUAL INDUCTANCE

open access: yes, 1992
The aim of the work is to make the class of the electric energy converters providing the electromagnetic compatibility with network and load, on base of the discrete resonant devices with mutual inductance and to investigate the electromagnetic processes
Roginskaya, Lubov Emmanuilovna
core  

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