Results 81 to 90 of about 402,756 (276)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Detection of Respiration Movement Asymmetry Between the Left and Right Lungs Using Mutual Information and Transfer Entropy

IEEE Access, 2018
Using diagnostic imaging, asymmetry in the mechanic of the left and right lungs has been discovered in unilateral lung disease. Unilateral lung disease might affect information interaction between two lungs, which is often neglected in the study of lung ...
Lianrong Zheng, Yifan Li, Wenhui Chen, Qian Wang, Qing Jiang, Guanzheng Liu   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Bounds on the Excess Minimum Risk via Generalized Information Divergence Measures

Entropy
Given finite-dimensional random vectors Y, X, and Z that form a Markov chain in that order (Y→X→Z), we derive the upper bounds on the excess minimum risk using generalized information divergence measures.
Ananya Omanwar, Fady Alajaji, Tamás Linder   +2 more
doaj   +1 more source

The mutual information of a stochastic binary channel: validity of the Replica Symmetry Ansatz

, 1998
We calculate the mutual information (MI) of a two-layered neural network with noiseless, continuous inputs and binary, stochastic outputs under several assumptions on the synaptic efficiencies.
Antonio Turiel, Atick J J, Atick J J, Barlow H B, Blahut R E, Cover T M, Dominguez D R C, Elka Korutcheva, Hertz J A, Korutcheva E, Laughlin S B, Linsker R, Mezard M, Nadal J P, Nadal J-P, Néstor Parga, Rudin W, Schultz S, Shannon C E, Treves A, van Hateren J H, van Hateren J H   +21 more
core   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Reducing Uncertainty of Weak Supervised Signals via Mutual Information Techniques

IEEE Access
Weakly supervised learning (WSL) refers to training models using imperfect or noisy labels, which can significantly reduce the costs associated with manual labeling.
Yichen Liu, Hanlin Feng, Xin Zhang
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Decoding MRI-informed brain age using mutual information

Insights into Imaging
Objective We aimed to develop a standardized method to investigate the relationship between estimated brain age and regional morphometric features, meeting the criteria for simplicity, generalization, and intuitive interpretability.
Jing Li, Linda Chiu Wa Lam, Hanna Lu
doaj   +1 more source