Results 71 to 80 of about 24,502 (300)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Bounds on the Excess Minimum Risk via Generalized Information Divergence Measures

Entropy
Given finite-dimensional random vectors Y, X, and Z that form a Markov chain in that order (Y→X→Z), we derive the upper bounds on the excess minimum risk using generalized information divergence measures.
Ananya Omanwar, Fady Alajaji, Tamás Linder   +2 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Reducing Uncertainty of Weak Supervised Signals via Mutual Information Techniques

IEEE Access
Weakly supervised learning (WSL) refers to training models using imperfect or noisy labels, which can significantly reduce the costs associated with manual labeling.
Yichen Liu, Hanlin Feng, Xin Zhang
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Decoding MRI-informed brain age using mutual information

Insights into Imaging
Objective We aimed to develop a standardized method to investigate the relationship between estimated brain age and regional morphometric features, meeting the criteria for simplicity, generalization, and intuitive interpretability.
Jing Li, Linda Chiu Wa Lam, Hanna Lu
doaj   +1 more source

Kolmogorov Capacity with Overlap

Entropy
The notion of δ-mutual information between non-stochastic uncertain variables is introduced as a generalization of Nair’s non-stochastic information functional.
Anshuka Rangi, Massimo Franceschetti
doaj   +1 more source

A Minimax Mutual Information Scheme for Supervised Feature Extraction and Its Application to EEG-Based Brain-Computer Interfacing

EURASIP Journal on Advances in Signal Processing, 2008
This paper presents a novel approach for efficient feature extraction using mutual information (MI). In terms of mutual information, the optimal feature extraction is creating a feature set from the data which jointly have the largest dependency on the ...
Farid Oveisi, Abbas Erfanian
doaj   +1 more source

The effect of anisotropy on holographic entanglement entropy and mutual information

Physics Letters B, 2019
We study the effect of anisotropy on holographic entanglement entropy (HEE) and holographic mutual information (MI) in the Q-lattice model, by exploring the HEE and MI for infinite strips along arbitrary directions.
Peng Liu, Chao Niu, Jian-Pin Wu
doaj   +1 more source