Results 41 to 50 of about 888,327 (305)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

'Only You': The Emergence of a Temperate Mutual Trust in the Area of Freedom, Security and Justice and Its Underpinning in the European Composite Constitutional Order

open access: yesEuropean Papers, 2017
(Series Information) European Papers - A Journal on Law and Integration, 2017 2(1), 141-157 | Article | (Table of Contents) I. Introduction: one or many faces of mutual trust in European integration? - II.
Luisa Marin
doaj   +1 more source

Towards a European Right to Claim Innocence?

open access: yesEuropean Papers, 2021
(Series Information) European Papers - A Journal on Law and Integration, 2020 5(3), 1325-1340 | Article | (Table of Contents) I. EU law and revision. - II. The nature of revision and (Western) European grounds. - II.1.
Joost Nan, Sjarai Lestrade
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Transnational Criminal Proceedings, Witness Evidence and Confrontation: Lessons from the ECtHR’s Case Law

open access: yesUtrecht Law Review, 2013
A single European area of freedom, security and justice requires new models of judicial cooperation in criminal matters to be put in place in order to efficiently combat transnational organized crime.
Lorena Bachmaier Winter
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Influence of correlations on molecular recognition

open access: yes, 2008
The influence of the patchiness and correlations in the distribution of hydrophobic and polar residues at the interface between two rigid biomolecules on their recognition ability is investigated in idealised coarse-grained lattice models.
B. Alberts   +9 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Transatlantic Integration and Developed Countries Competitiveness Problems

open access: yesVestnik MGIMO-Universiteta, 2016
Factors and possible consequences of transatlantic integration are elaborated in the article. An overview of the history of transatlantic cooperation is provided. The author highlights the paramount goal of Transatlantic Trade and Investment Partnership (
Alexey. A. Sidorov
doaj   +3 more sources

Mutual recognition between ewes and lambs [PDF]

open access: yesReproduction Nutrition Développement, 1980
Studies to investigate the relative value of sight, hearing and smell in mutual recognition between ewes and lambs are described. The method used was to alter clues that could aid in recognition, rather than interfering with the animal's sensory perception. When lambs were coloured with powdered dyes to change appearance, this produced marked avoidance
Shillito Walser, Elizabeth   +1 more
openaire   +3 more sources

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