Results 41 to 50 of about 1,988,115 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Managing diversity: The European Arrest Warrant and the potential of mutual recognition as a mode of governance in EU Justice and Home Affairs [PDF]
, 2007 [From the introduction]. Mutual recognition is the central mode of governance in the Single Market which helped to overcome trade barriers caused by differences in national product regulation.
Sievers, Julia.
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mutual recognition of enantiomers.
Journal of Synthetic Organic Chemistry, Japan, 1990 Homochiral or heterochiral interaction of enantiomers is a fundamental principle in crystal lattice formation, giving either racemates or conglomerates, and multi-stage interactions. Such diastereomeric effects arising from labile molecular assembly are also significant in various solution-phase phenomena related to physical, spectroscopic, and ...
NOYORI, Ryoji, OKADA, Shigemitsu
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The Application of the Principle of Mutual Recognition in EU Criminal Law Matters - Internally and Externally vis-à-vis Pre-Accession Policy [PDF]
, 2020 This thesis analyses the principle of mutual recognition in EU criminal matters from two perspectives. It argues that the framework upon which this principle is built has become increasingly problematic and that the issues questioning its justification ...
Spreeuw, M.
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Holistic Integrative OncologyWith the continuous advancement of medical research, the number of multi-center clinical studies has been steadily increasing, bringing about significant challenges to ethical review.
Xiaolin Liu +5 more
doaj +1 more source
Perspectives on Federalism, 2016 European Union, and criminal, laws had been interacting in many ways even before explicit competence in criminal matters was acquired by the Union in the Treaty of Maastricht.
Mancano Leandro
doaj +1 more source