Results 41 to 50 of about 1,438,650 (287)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of Organizational Cultural Differences and Mutual Trust on Contract Management of Nonequity Construction Project Alliances

open access: yesAdvances in Civil Engineering, 2018
This study aims to examine the impact of organizational cultural difference and mutual trust on the contract management of nonequity project alliances in the construction industry. A questionnaire survey was conducted to collect the quantitative data for
Yanling Zhao, Yingbin Feng, Chenggang Li
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A New Crack in the Wall of Mutual Recognition and Mutual Trust: Ne Bis in Idem and the Notion of Final Decision Determining the Merits of the Case

open access: yesEuropean Papers, 2017
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(3), 1183-1193 | European Forum Insight of 5 January 2017 | (Table of Contents) I.
Stefano Montaldo
doaj   +1 more source

The Systemic Equivalence Test and the Presumption of Equivalent Protection in European Human Rights Law—A Critical Appraisal

open access: yesGerman Law Journal, 2023
The systemic equivalence test constitutes an important tool in European Human Rights Law: It is used in order to structure the different systems of protection that apply in a common space and to common addressees. More precisely, where there is “systemic”
Cecilia Rizcallah
doaj   +1 more source

Sincere Cooperation, Mutual Trust, and Mutual Recognition in Social Security Coordination [PDF]

open access: yes, 2020
This article looks into the meaning of the concepts of sincere cooperation,mutual trust, and mutual recognition in EU social security coordination. Itanalyses the legislative choice of coordination as the main regulatory mechanism in the field, and ...
Wenander, Henrik   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

An initial analysis of South African mutual fund expenses [PDF]

open access: yes, 2010
Includes bibliographical references (leaves 91-97).The following research aims to collect and collate a set of data relating to characteristics of mutual funds within the South African Mutual Fund Industry, with a specific focus on expenses. In addition,
Griffiths, James
core   +1 more source

Towards a European Right to Claim Innocence?

open access: yesEuropean Papers, 2021
(Series Information) European Papers - A Journal on Law and Integration, 2020 5(3), 1325-1340 | Article | (Table of Contents) I. EU law and revision. - II. The nature of revision and (Western) European grounds. - II.1.
Joost Nan, Sjarai Lestrade
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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