Results 41 to 50 of about 85,417 (299)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Innovating social connectedness for agricultural innovations in eastern Ethiopia

open access: yesCogent Food & Agriculture, 2020
Agricultural innovations can be triggered by the social networks in which farmers have purposefully organized to support themselves. This paper, therefore, explores the values of social connectedness within locally established societies’ mutual support ...
Desalegn Yadeta Wedajo   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

An initial analysis of South African mutual fund expenses [PDF]

open access: yes, 2010
Includes bibliographical references (leaves 91-97).The following research aims to collect and collate a set of data relating to characteristics of mutual funds within the South African Mutual Fund Industry, with a specific focus on expenses. In addition,
Griffiths, James
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A New Crack in the Wall of Mutual Recognition and Mutual Trust: Ne Bis in Idem and the Notion of Final Decision Determining the Merits of the Case

open access: yesEuropean Papers, 2017
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(3), 1183-1193 | European Forum Insight of 5 January 2017 | (Table of Contents) I.
Stefano Montaldo
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMPARISON OF THE PERFORMANCE OF ISLAMIC MUTUAL FUNDS vs. ETHICAL AND CONVENTIONAL MUTUAL FUNDS [PDF]

open access: yes, 2013
Mutual funds are one of the key contributors to the globalisation of financial markets and one of the main sources of capital flows to emerging economies.
ALRASHIDI, FALEH,M,F,E
core  

The European Model of Judicial Cooperation in Criminal Matters: Towards Effectiveness based on Earned Trust

open access: yesRevista Brasileira de Direito Processual Penal, 2019
The EU model of international judicial cooperation in criminal matters, based on a high level of presumed mutual trust among Member States and on the principle of mutual recognition resulting therefrom, purports to go beyond traditional models of ...
Valsamis Mitsilegas
doaj   +1 more source

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